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Brown Alga Metabolites – Inhibitors of Marine Organism Fucoidan Hydrolases

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Chemistry of Natural Compounds Aims and scope

Fucoidan hydrolase inhibitors were discovered for the first time. Metabolites in the aqueous EtOH extract of Fucus evanescens inhibited specifically the activity of enzymes involved in catabolism of brown-alga polysaccharides, i.e., fucoidanases (recombinant FFA from the marine bacterium Formosa algae KMM 3553T and PPF from the marine mollusk Patinopecten yessoensis) and glycosidases (recombinant α-L-fucosidase FucFa from F. algae and β-D-glucosidase G-II from the marine mollusk Littorina sitkana). The purified fucophlorethol fraction isolated from this extract inhibited recombinant fucoidanase FFA in the concentration range 10–50 μg/mL.

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Acknowledgment

The work was supported by RFBR Grant No. 15-04-01004.

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Authors and Affiliations

  1. G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-East Branch, Russian Academy of Sciences, 159 Prosp. 100 Let Vladivostoku, Vladivostok, 690022, Russia

    A. S. Silchenko, T. I. Imbs, T. N. Zvyagintseva, S. A. Fedoreyev & S. P. Ermakova

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  1. A. S. Silchenko
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  2. T. I. Imbs
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  3. T. N. Zvyagintseva
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  4. S. A. Fedoreyev
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  5. S. P. Ermakova
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Correspondence to T. N. Zvyagintseva.

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Silchenko, A.S., Imbs, T.I., Zvyagintseva, T.N. et al. Brown Alga Metabolites – Inhibitors of Marine Organism Fucoidan Hydrolases. Chem Nat Compd 53, 345–350 (2017). https://doi.org/10.1007/s10600-017-1985-4

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  • DOI: https://doi.org/10.1007/s10600-017-1985-4

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