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A New Ursane Triterpenoid Possessing Cytotoxicity from the Fruits of Vitex trifolia var. simplicifolia

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Chemistry of Natural Compounds Aims and scope

A new ursane-type triterpene, 3β-hydroxy-30-al-urs-12-en-28-oic acid (1), was isolated from the MeOH extract of the fruits of Vitex trifolia var. simplicifolia, along with seven known compounds: ursolic acid (2), taraxerol (3), taraxerone (4), α-amyrin (5), β-amyrin (6), lupeol (7), and betulinic acid (8). Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. The cytotoxicity of compounds 1–8 were evaluated in vitro against four human tumor cell lines (HL-60, SGC-7901, PANC-1, and Eca-109). Compound 1 showed significant cytotoxic activity.

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Acknowledgment

This work was sponsored by the Natural Science Foundation of Fujian Province (No. 2010J01179) and the Open Project of National Marine Bureau Key Laboratory of Marine Biogenetic Resources (HY 201506).

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Authors and Affiliations

  1. Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 350004, Fuzhou, P. R. China

    Mingyu Huang, Lei Zhang, Fang Zhou, Xinhua Ma, Zhijun Li & Yonghong Zhang

  2. Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, 361005, Xiamen, P. R. China

    Tianhua Zhong

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  1. Mingyu Huang
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  2. Lei Zhang
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  3. Fang Zhou
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  4. Xinhua Ma
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  5. Zhijun Li
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  6. Tianhua Zhong
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  7. Yonghong Zhang
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Corresponding authors

Correspondence to Tianhua Zhong or Yonghong Zhang.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2016, pp. 569–571.

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Huang, M., Zhang, L., Zhou, F. et al. A New Ursane Triterpenoid Possessing Cytotoxicity from the Fruits of Vitex trifolia var. simplicifolia . Chem Nat Compd 52, 660–663 (2016). https://doi.org/10.1007/s10600-016-1733-1

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  • DOI: https://doi.org/10.1007/s10600-016-1733-1

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