An approach using acetylenes was used and optimized to synthesize rare natural ω6 polyene fatty acids. The key synthetic step was cross-coupling of a propargyl derivative with a terminal acetylene in the presence of equimolar amounts of Cu(I).
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The work was performed under the auspices of State Task of the Russian Ministry of Education and Science, Project No. 4.128.2014/K.
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Translated from Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2015, pp. 28–31.
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Golovanov, A.B., Ganina, K.D., Groza, N.V. et al. Synthesis of the ω6 (5Z,8Z)-Tetradecadienoic and (7Z,10Z)-Hexadecadienoic Polyene Fatty Acids. Chem Nat Compd 51, 26–30 (2015). https://doi.org/10.1007/s10600-015-1195-x
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DOI: https://doi.org/10.1007/s10600-015-1195-x