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Structure of Acid Hydrolysate of Total Ginsenosides and Their Cytotoxic Activity

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Chemistry of Natural Compounds Aims and scope

Bioassay-guided fractionation of the cytotoxic acid hydrolysate of the total ginsenosides of Panax ginseng C. A. Meyer (Araliaceae) afforded a new ginsenoside, (20S,22S)-dammar-22,25-epoxy-3β,12β,20-triol (1), along with five known ginsenosides, 20R,24R-dammar-20(24)-epoxy-3β,12β,25-triol (2), 20R-panaxdiol (3), dammar-(E)-20(22)-ene-3β,12β,25-triol (4), 20R-protopanaxadiol (5), and 20R-dammar-25-ethoxy-3β,12β,20-triol (6). Their structures were elucidated on the basis of spectroscopic data. Among the compounds isolated, compound 1 showed strong cytotoxic activity against human cancer cell lines SW1116, HCT116, and A549.

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Acknowledgment

This project was financially supported by National Natural Science Foundation of China (No. 31070308) and Key Project of the National Eleventh-Five Year Research Program of China (2009ZX09103-365). We are also grateful to the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences for providing spectroscopic data.

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Authors and Affiliations

  1. Department of Natural Product Chemistry, School of Pharmacy, Jilin University, 130021, Changchun, P. R. China

    Jingyan Liu, Yuxia Yang, Jianyuan Yin, Jihua Liu, Wei Li, Cong Geng, Dandan Sun, Fanbo Chen, Xiaoyu Yan, Mengtian Liu, Yushan Cao & Qin Meng

  2. Beijing Laviana Pharmatech Co., Ltd., 102206, Beijing, P. R. China

    Wei Li

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  1. Jingyan Liu
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  2. Yuxia Yang
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  10. Mengtian Liu
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Corresponding author

Correspondence to Qin Meng.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2014, pp. 595–597.

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Liu, J., Yang, Y., Yin, J. et al. Structure of Acid Hydrolysate of Total Ginsenosides and Their Cytotoxic Activity. Chem Nat Compd 50, 687–690 (2014). https://doi.org/10.1007/s10600-014-1053-2

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  • DOI: https://doi.org/10.1007/s10600-014-1053-2

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