The semicarbazone and isonicotinoylhydrazone of 5α-pregn-2-en-20-one, which was prepared from 3β-acetoxy-5α-pregn-16-en-20-one, were synthesized for the first time. The antituberculosis activity of these and semicarbazones and isonicotinoylhydrazones of saturated, unsaturated, and adamantane-modified ketosteroids synthesized by us earlier was studied in vitro experiments.
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Acknowledgment
We thank C. Kwong, Coordinator of the TAACF-USA program, for leading the biological tests. The work was supported financially by the Sh. Rustaveli Georgian National Foundation (Grant No. GNSF/ST08/4-406).
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Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2012, pp. 382–384.
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Sikharulidze, M.I., Nadaraia, N.S. & Kakhabrishvili, M.L. Synthesis and antituberculosis activity of several steroids from 3β-acetoxy-5α-pregn-16-en-20-one. Chem Nat Compd 48, 423–425 (2012). https://doi.org/10.1007/s10600-012-0265-6
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DOI: https://doi.org/10.1007/s10600-012-0265-6