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Synthesis and antimicrobial activities of 4-aryl-3,4-dihydrocoumarins and 4-arylcoumarins

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Chemistry of Natural Compounds Aims and scope

A new series of 4-aryl-3,4-dihydrocoumarins and 4-arylcoumarins were synthesized by the reaction of substituted cinnamic acids and 3-arylpropiolic acid with the corresponding phenols. These compounds were evaluated for antibacterial activity in vitro. The synthesized compounds displayed different degrees of antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Bacillus dysenteriae, and Candida albicans (a fungus). Compounds with catechol moieties and 7,8-substituted dihydroxyls in the A ring were the most active antimicrobial agents.

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Acknowledgment

This work was financially supported by the Science and Technology Program of Guangdong Province, Strategic Cooperation Program between Guangdong Province and Chinese Academy of Sciences and Core Technology Program for Strategic Emerging Industries of Guangdong Province (2006B35604002, 2009B091300125, and 2011A081401002).

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Authors and Affiliations

  1. Guangzhou Institute of Chemistry, Chinese Academy of Sciences, Guangzhou, 510650, P. R. China

    Jie Sun & Yong Zou

  2. Department of Zoology, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, P. R. China

    Wei-Xian Ding, Xiao-Ping Hong & Ke-Yun Zhang

  3. Graduate School of the Chinese Academy of Science, Beijing, 100039, P. R. China

    Jie Sun

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  1. Jie Sun
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  2. Wei-Xian Ding
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  3. Xiao-Ping Hong
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  4. Ke-Yun Zhang
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  5. Yong Zou
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Corresponding authors

Correspondence to Ke-Yun Zhang or Yong Zou.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 20–25, January–February, 2012.

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Sun, J., Ding, WX., Hong, XP. et al. Synthesis and antimicrobial activities of 4-aryl-3,4-dihydrocoumarins and 4-arylcoumarins. Chem Nat Compd 48, 16–22 (2012). https://doi.org/10.1007/s10600-012-0149-9

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  • DOI: https://doi.org/10.1007/s10600-012-0149-9

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