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A novel daphnane-type diterpene from the flower bud of Daphne genkwa

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Chemistry of Natural Compounds Aims and scope

A novel daphnane-type diterpene, genkwanin I (1), and a novel natural product, orthobenzoate 2 (2), were isolated from the flower bud of Daphne genkwa. The structures of the two compounds were elucidated by spectral techniques, viz.1D, 2D NMR spectra and HR-ESI-MS. Genkwanin I showed inhibitory activity against human promyelocytic HL-60 cells at an IC50 level of 11.74 μM.

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Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (Grant No. 30973868). The authors wish to thank Prof. Qishi Sun, Department of Traditional Chinese Nateria Medica, Shenyang Pharmaceutical University, for the identification of the plant material.

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Authors and Affiliations

  1. School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Desig n & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, China

    L. Z. Li, P. Y. Gao & S. J. Song

  2. School of Pharmacy, Shenyang Pharmaceutical University, 110016, Shenyang, China

    Y. Peng & L. H. Wang

Authors
  1. L. Z. Li
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  2. P. Y. Gao
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  3. Y. Peng
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  4. L. H. Wang
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  5. S. J. Song
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Corresponding author

Correspondence to S. J. Song.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 321–323, May–June, 2010.

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Li, L.Z., Gao, P.Y., Peng, Y. et al. A novel daphnane-type diterpene from the flower bud of Daphne genkwa . Chem Nat Compd 46, 380–382 (2010). https://doi.org/10.1007/s10600-010-9622-5

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  • DOI: https://doi.org/10.1007/s10600-010-9622-5

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