The 1→3;1→6-β-D-glucan chrysolaminaran with molecular weight 8.5 kDa and 3.6:1 ratio of 1→3:1→6 bonds was isolated from cultivated diatom alga Synedra acus and characterized. It was shown that the isolated chrysolaminaran inhibited growth and colony formation of human colon tumor cells.
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Acknowledgment
The work was supported by the Russian Foundation for Basic Research (No. 09-04-00761), the RAS program “Molecular and Cellular Biology,” and RAS Program No. 22.03, Grant FEB RAS.
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Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 5–8, January–February, 2010.
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Kusaikin, M.I., Ermakova, S.P., Shevchenko, N.M. et al. Structural characteristics and antitumor activity of a new chrysolaminaran from the diatom alga Synedra acus . Chem Nat Compd 46, 1–4 (2010). https://doi.org/10.1007/s10600-010-9510-z
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DOI: https://doi.org/10.1007/s10600-010-9510-z