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Synthesis and HIV-1 RNase H-activity of new alizarin acetonyl derivatives

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Chemistry of Natural Compounds Aims and scope

Alkylation of 1,2-dihydroxyanthraquinone (alizarin) by α-bromoacetone was studied and its β-acetonyl derivative was chemically modified. The composition and structure of the products were confirmed by elemental analysis; UV, IR, PMR, and 13C NMR spectroscopy; and mass spectrometry. The synthesized derivatives were tested as inhibitors of HIV-1 RNase H.

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Acknowledgment

We thank Prof. E. Tramontano for assistance in testing samples for HIV-1 RNase H-activity.

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Authors and Affiliations

  1. A. B. Bekturov Institute of Chemical Sciences, Republic of Kazakhstan, Almaty, ul. Sh. Ualikhanova, 106

    T. V. Kharlamova

  2. Department of Biomedical Science and Technology, University of Cagliari, Cagliari, Italy

    T. V. Kharlamova

Authors
  1. T. V. Kharlamova
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Correspondence to T. V. Kharlamova.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 531–534, September–October, 2009.

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Kharlamova, T.V. Synthesis and HIV-1 RNase H-activity of new alizarin acetonyl derivatives. Chem Nat Compd 45, 629–633 (2009). https://doi.org/10.1007/s10600-009-9443-6

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  • DOI: https://doi.org/10.1007/s10600-009-9443-6

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