Abstract
To examine measures for managing mentally disordered patients in communities, this study aimed to examine the association between medication adherence (MA) and disease stability (DS), and their area variations in a sample of 145,860 patients with severe mental disorders in 19 municipalities during 2006–2013 in southwest China. The rates of stability and adherence varied from 27.7–64.4% to 28.8–63.6%, respectively, over the same period. MA was positively associated with DS (adjusted odds ratio = 1.39, 95% confidence interval 1.29–1.51). Large variations in the rate of DS and MA among municipalities could reflect management differences at this level.
Notes
Government regulations prevent data publication. All information that could be used to recognize personal identities, including names, ID numbers, and addresses have been concealed.
References
Chang, C. K., Hayes, R. D., Perera, G., Broadbent, M. T., Fernandes, A. C., Lee, W. E., et al. (2011). Life expectancy at birth for people with serious mental illness and other major disorders from a secondary mental health care case register in London. PLoS ONE,6(5), e19590. https://doi.org/10.1371/journal.pone.0019590.
Charlson, F. J., Baxter, A. J., Cheng, H. G., Shidhaye, R., & Whiteford, H. A. (2016). The burden of mental, neurological, and substance use disorders in China and India: A systematic analysis of community representative epidemiological studies. The Lancet,388(10042), 376–389. https://doi.org/10.1016/S0140-6736(16)30590-6.
Hong, M., Jin, L., Yanlin, H., Bin, X., Yifeng, X., & Wei, H. (2011). An important pathway of mental health service reform in China: Introduction of 686 program. Chinese Mental Health Journal,25(10), 725–729.
Hong, W., Xuanyin, H., Xiaoqiong, L., et al. (2012). Analysis on situation of patients with severe mental illness in Sichuan in 2011. Sichuan Mental Health,25(4), 200–203. (in Chinese).
Lau, J. T. F., Cheng, Y., Gu, J., Zhou, R. A., Yu, C. P., Holroyd, E., et al. (2012). Suicides in a mega-size factory in China: Poor mental health among young migrant workers in China. Occupational and Environmental Medicine,69(7), 526. https://doi.org/10.1136/oemed-2011-100593.
Ministry of China. (2012). Chinese managerial and treatment regulations for severely mentally disordered patients (in Chinese).
Mou, J., Griffiths, S. M., Fong, H., & Dawes, M. G. (2013). Health of China’s rural-urban migrants and their families: A review of literature from 2000 to 2012. British Medical Bulletin,106, 19–43. https://doi.org/10.1093/bmb/ldt016.
Mutsatsa, S. H., Joyce, E. M., Hutton, S. B., Webb, E., Gibbins, H., Paul, S., et al. (2003). Clinical correlates of early medication adherence: West London first episode schizophrenia study. Acta Psychiatrica Scandinavica,108(6), 439–446.
National Bureau of Statistics of China. (2007) China Statistical Yearbook.
National Bureau of Statistics of China. (2014) China Statistical Yearbook.
Qiu, X., Ju, K., Zheng, H., Niu, X., Tang, A., Zhang, X., et al. (2015). Characteristics comparison between registered and floating troublemaking psychopaths in Changning district. Shanghai Journal of Preventive Medicine,31(3), 193–196.
Rasbash, J., Steele, F., Browne, W. J., & Goldstein, H. (2012). A user’s guide to MLwiN, version 2.26 (p. 306). Bristol: University of Bristol.
Subotnik, K. L., Nuechterlein, K. H., Ventura, J., Gitlin, M. J., Marder, S., Mintz, J., et al. (2011). Risperidone nonadherence and return of positive symptoms in the early course of schizophrenia. American Journal of Psychiatry,168(3), 286–292. https://doi.org/10.1176/appi.ajp.2010.09010087.
Wen, H., Wang, D., Wang, W., & Yang, X. (2014). The state of death and the cause of death insevere psychotic patients who were managed in Sichuan, 2011–2013. Sichuan Mental Health,27(4), 337–340. (in Chinese).
WHO-Wonca Report. (2008). Integrating mental health into primary care. A global perspective. Geneva, 197(10), 791.
Wu, H., Zhang, W., & Xu, L. (2014). Factors related with schizophrenia relapse and management. Chinese Journal of Rehabilitation Theory and Practice,20(4), 378–381.
Zhou, W., & Xiao, S. (2015). Reporting on China’s mental health surveillance. American Journal of Psychiatry,172(4), 314–315. https://doi.org/10.1176/appi.ajp.2015.14070945.
Acknowledgements
The publication is based on data collected by hundreds of mental health professionals in communities. We acknowledge and thank them for managing this information.
Funding
This work was supported by China Medical Board (Grant No. CMB 12-106). The funders had no role in the design, execution, analyses or data interpretation for this study, or in the decision to submit the results for publication.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Li, Y., Wen, H., Xu, J. et al. The Association Between Medication Adherence and Disease Stability in Patients with Severe Mental Disorders and Area Variation: Community-Based Prospective Study in Southwest China. Community Ment Health J 56, 322–327 (2020). https://doi.org/10.1007/s10597-019-00460-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10597-019-00460-2