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Synthesis of new 2-substituted 3-(tri(di)fluoromethyl)-quinoxalines from 3-(trifluoromethyl)quinoxalin-2(1H)-oneand 3-(tri(di)fluoromethyl)quinoxaline-2-carboxylic acids

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Chemistry of Heterocyclic Compounds Aims and scope

Starting from 3-(trifluoromethyl)quinoxalin-2(1H)-one, a wide range of new 2-substituted 3-(trifluoromethyl)quinoxalines were obtained, including amino, bromo, chloro, hydrazino, phenyl, α-furyl, formyl, methylsulfanyl, and methylsulfonyl derivatives. 3-(Tri(di)-fluoromethyl)quinoxaline-2-carboxylic acids were obtained for the first time and used for the synthesis of 2-amino-3-(tri(di)-fluoromethyl)quinoxalines and 2-(2-aminothiazol-4-yl)-3-(trifluoromethyl)quinoxaline.

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This work was performed with financial support from the Federal Ministry of Industry and Technology of Germany (project EP101205). A part of this research was presented at the conference " Organic synthesis: chemistry and technology" , Yekaterinburg, Russia, June 04–08, 2012.

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Authors and Affiliations

  1. Hansa Fine Chemicals GmbH, BITZ, 1 Fahrenheitstr., Bremen, 28359, Germany

    Andrey V. Didenko, Mikhail V. Vorobiev & Dmitri V. Sevenard

  2. Institute of Natural Sciences, Ural Federal University named after the first President of Russia B.N.Yeltsin, 51 Lenina Ave., Yekaterinburg, 620000, Russia

    Vyacheslav Ya. Sosnovskikh

Authors
  1. Andrey V. Didenko
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  2. Mikhail V. Vorobiev
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  3. Dmitri V. Sevenard
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  4. Vyacheslav Ya. Sosnovskikh
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Correspondence to Dmitri V. Sevenard.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(3), 259–268

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Didenko, A.V., Vorobiev, M.V., Sevenard, D.V. et al. Synthesis of new 2-substituted 3-(tri(di)fluoromethyl)-quinoxalines from 3-(trifluoromethyl)quinoxalin-2(1H)-oneand 3-(tri(di)fluoromethyl)quinoxaline-2-carboxylic acids. Chem Heterocycl Comp 51, 259–268 (2015). https://doi.org/10.1007/s10593-015-1694-5

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