Abstract
An understanding of pattern recognition receptors (PRRs) and immunomodulatory approach based on activation of these receptors has provided insights critical for the management of neurological health disorders. Toll-like receptors (TLRs) are one of the most widely explored PRRs and have been exploited in the recent past for development of novel immunomodulatory therapeutic agents. Glioblastoma multiforme is characterized by significant infiltration of resident microglia and expresses all the members of the TLR family. The present report is focused on exciting findings pertaining to probable implications of TLR9 activation by unmethylated CG sequences for novel therapeutic intervention against glioblastoma multiforme, which could be a discrete step toward the effective management of neurological health issues.
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Funding
Bajpai P and Tiwari RK would extend their gratitude toward Science Engineering and Research Board (SERB), New Delhi, India for financially assisting this study (Grant No: YSS/2014/000106).
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Tiwari, R.K., Singh, S., Gupta, C.L. et al. Microglial TLR9: Plausible Novel Target for Therapeutic Regime Against Glioblastoma Multiforme. Cell Mol Neurobiol 41, 1391–1393 (2021). https://doi.org/10.1007/s10571-020-00925-z
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DOI: https://doi.org/10.1007/s10571-020-00925-z