Summary
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1.
To test whether an ischemic insult increases the susceptibility to cyclosporine A (CsA)-induced neurotoxicity, we examined the effect of CsA on the minimal electroshock-induced convulsions in mice treated with a transient middle cerebral artery occlusion (MCAO) for a short period (2 h).
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This MCAO produced small to mid-sized infarcted regions in the cerebral hemisphere with increasing post-operative days. In MCAO mice, CsA (30 mg/kg, i.p.) elevated the incidence of minimal electroshock-induced convulsions to 90–100% over that in sham mice (20–30%) at 1–7 days but not 14 days post-surgery.
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In light of these findings, the possibility that CsA increases the risk of convulsions in patients with cerebral infarction and/or at an early stage following focal cerebral ischemia would have to be considered.
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Yamauchi, A., Shuto, H., Dohgu, S. et al. Cyclosporin A Aggravates Electroshock-Induced Convulsions in Mice with a Transient Middle Cerebral Artery Occlusion. Cell Mol Neurobiol 25, 923–928 (2005). https://doi.org/10.1007/s10571-005-4956-5
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DOI: https://doi.org/10.1007/s10571-005-4956-5