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Effect of Paclitaxel-Coated Balloon Angioplasty on Side Branch Lesion and Cardiovascular Outcomes in Patients with De Novo True Coronary Bifurcation Lesions Undergoing Percutaneous Coronary Intervention

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Abstract

Purpose

To compare the effects of paclitaxal-coated balloon (PCB) versus conventional balloon (CB) on side branch (SB) lesion and cardiovascular outcomes in patients with de novo true bifurcation lesions.

Methods

In total, 219 patients with de novo true bifurcation lesions were enrolled and divided into PCB group (102 cases) and CB group (117 cases) according to angioplasty strategy in SB. Drug-eluting stent (DES) was implanted in main vessel (MV) for each subject. All subjects underwent a 12-month follow-up for late lumen loss (LLL), restenosis, and major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI). MACEs included cardiac death, nonfatal myocardial infarction, and unstable angina requiring admission.

Results

There were no differences in diameter, minimum lumen diameter (MLD), and stenosis for bifurcation lesions between the two groups before and immediately after PCI (P > 0.05). After 12-month follow-up, no differences occurred in MV-MLD and MV-LLL between the two groups (P > 0.05); SB-MLD in PCB group was higher than that in CB group (1.97 ± 0.36 mm vs. 1.80 ± 0.43 mm, P = 0.007); SB-LLL in PCB group was lower than that in CB group (0.11 ± 0.18 mm vs. 0.19 ± 0.25 mm, P = 0.024). Multivariate COX analyses indicated that PCB group had lower MACE risk than CB group (HR = 0.480, 95%CI 0.244–0.941, P = 0.033).

Conclusion

PCB could decrease SB-LLL and MACE risk in patients with de novo true coronary bifurcation lesion 12 months after single-DES intervention.

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Data Availability

The data used to support the findings of this study are available from the corresponding author upon request.

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Funding

This study was funded by the Natural Science Foundation of Chongqing (grant no. cstc2017jcyjAX0042).

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Author notes

  1. Youmei Li and Qi Mao contributed equally to this paper.

Authors and Affiliations

  1. Department of Cardiology, Institute of Cardiovascular Research, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China

    Youmei Li, Qi Mao, Huanyun Liu, Denglu Zhou & Jianhua Zhao

  2. Department of Cardiology, First People’s Hospital of Liang Jiang New Area, Chongqing, 401121, China

    Huanyun Liu

Authors
  1. Youmei Li
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  2. Qi Mao
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  3. Huanyun Liu
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  4. Denglu Zhou
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Contributions

Qi Mao contributed to the study conception and design. Youmei Li and Huanyun Liu analyzed the patient data regarding coronary angiograph. Data collection was performed by Denglu Zhou and Jianhua Zhao. The first draft of this manuscript was written by Youmei Li and Qi Mao. All authors commented previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Qi Mao.

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All procedures performed in this study involving human participants were in accordance with the ethical standards of the institution (ethics committee of Xinqiao Hospital, Chongqing). Informed consent was obtained from all individual participants of this study.

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The authors declare no competing interests.

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Li, Y., Mao, Q., Liu, H. et al. Effect of Paclitaxel-Coated Balloon Angioplasty on Side Branch Lesion and Cardiovascular Outcomes in Patients with De Novo True Coronary Bifurcation Lesions Undergoing Percutaneous Coronary Intervention. Cardiovasc Drugs Ther 36, 859–866 (2022). https://doi.org/10.1007/s10557-021-07225-8

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