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Emerging technology: applications of Raman spectroscopy for prostate cancer

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Abstract

There is a need in prostate cancer diagnostics and research for a label-free imaging methodology that is nondestructive, rapid, objective, and uninfluenced by water. Raman spectroscopy provides a molecular signature, which can be scaled from micron-level regions of interest in cells to macroscopic areas of tissue. It can be used for applications ranging from in vivo or in vitro diagnostics to basic science laboratory testing. This work describes the fundamentals of Raman spectroscopy and complementary techniques including surface enhanced Raman scattering, resonance Raman spectroscopy, coherent anti-Stokes Raman spectroscopy, confocal Raman spectroscopy, stimulated Raman scattering, and spatially offset Raman spectroscopy. Clinical applications of Raman spectroscopy to prostate cancer will be discussed, including screening, biopsy, margin assessment, and monitoring of treatment efficacy. Laboratory applications including cell identification, culture monitoring, therapeutics development, and live imaging of cellular processes are discussed. Potential future avenues of research are described, with emphasis on multiplexing Raman spectroscopy with other modalities.

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Acknowledgments

This work was funded, in part by the Strauss TEAMS Endowed Chair, the Wayne State University Department of Surgery, and the Henry Ford Health System.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Smart Sensors and Integrated Microsystems Laboratories, Department of Electrical and Computer Engineering, Wayne State University, 5050 Anthony Wayne Drive, Room 3100, Detroit, MI, 48202, USA

    Rachel E. Kast, Kevin Killian, Micaela Trexler & Gregory W. Auner

  2. Bioactive Lipids Research Program (BLRP), Department of Pathology, Wayne State University School of Medicine, Detroit, MI, 48202, USA

    Stephanie C. Tucker & Kenneth V. Honn

  3. Karmanos Cancer Institute, Detroit, MI, USA

    Stephanie C. Tucker, Kenneth V. Honn & Gregory W. Auner

  4. Department of Surgery, Wayne State University School of Medicine, Detroit, MI, 48202, USA

    Gregory W. Auner

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  1. Rachel E. Kast
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  2. Stephanie C. Tucker
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  3. Kevin Killian
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  4. Micaela Trexler
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Correspondence to Gregory W. Auner.

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Kast, R.E., Tucker, S.C., Killian, K. et al. Emerging technology: applications of Raman spectroscopy for prostate cancer. Cancer Metastasis Rev 33, 673–693 (2014). https://doi.org/10.1007/s10555-013-9489-6

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