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Novel functions of TIMPs in cell signaling

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Abstract

Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of matrix metalloproteinases (MMPs) and the balance between MMPs/TIMPs regulates the extracellular matrix (ECM) turnover and remodeling during normal development and pathogenesis. Increasing evidence indicates a much more complex role for TIMPs during tumor progression and angiogenesis, in addition to their regulation of MMP-mediated ECM degradation. In this article, we review both the MMP-dependent and -independent actions of TIMPs for the regulation of cell death, cell proliferation, and angiogenesis, with a particular emphasis on TIMP-1 in the regulation of tetraspanin/integrin-mediated cell survival signal transduction pathways.

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  1. Ki-Kyung Jung

    Present address: Genetic Toxicology Division, National Institute of Toxicological Research, 5 Nokbun-dong, Eunpyung-gu, Seoul, 122-704, South Korea

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  1. Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan, 48201

    Rosemarie Chirco, Xu-Wen Liu, Ki-Kyung Jung & Hyeong-Reh Choi Kim

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Chirco, R., Liu, XW., Jung, KK. et al. Novel functions of TIMPs in cell signaling. Cancer Metastasis Rev 25, 99–113 (2006). https://doi.org/10.1007/s10555-006-7893-x

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