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Single breath hold 3D cardiac cine MRI using kat-ARC: preliminary results at 1.5T

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Abstract

Validation of a new single breath-hold, three-dimensional, cine balanced steady-state free precession (3D cine bSSFP) cardiac magnetic resonance (CMR) sequence for left ventricular function. CMR examinations were performed on fifteen patients and three healthy volunteers on a clinical 1.5T scanner using a two-dimensional (2D) cine balanced SSFP CMR sequence (2D cine bSSFP) followed by an investigational 3D cine bSSFP pulse sequence acquired within a single breath hold. Left ventricular end diastolic volume (LVEDV), end systolic volume (LVESV), ejection fraction (LVEF), and myocardial mass were independently segmented on a workstation by two experienced radiologists. Blood pool to myocardial contrast was evaluated in consensus using a Likert scale. Bland–Altman analysis was used to compare these quantitative and nominal measurements for the two sequences. The average acquisition time was significantly shorter for the 3D cine bSSFP than for 2D cine bSSFP (0.36 ± 0.03 vs. 8.5 ± 2.3 min) p = 0.0002. Bland–Altman analyses [bias and (limits of agreement)] of the data derived from these two methods revealed that the LVEF 0.9 % (−4.7, 6.4), LVEDV 4.9 ml (−23.0, 32.8), LVESV −0.2 ml (−22.4, 21.9), and myocardial mass −0.4 g (−23.8, 23.0) were not significantly different. There was excellent intraclass correlation for intra-observer variability (0.981, 0.989, 0.997, 0.985) and inter-observer variability (0.903, 0.954, 0.970, 0.842) for LVEF, LVEDV, LVESV, and myocardial mass respectively. 3D cine bSSFP allows for accurate single breath-hold volumetric cine CMR which enables substantial improvements in scanner time efficiency without sacrificing diagnostic accuracy.

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References

  1. Carr JC, Simonetti O, Bundy J, Li D, Pereles S, Finn JP (2001) Cine MR angiography of the heart with segmented true fast imaging with steady-state precession. Radiology 219(3):828–834

    Article  CAS  PubMed  Google Scholar 

  2. Makowski MR, Wiethoff AJ, Jansen CH, Uribe S, Parish V, Schuster A, Botnar RM, Bell A, Kiesewetter C, Razavi R, Schaeffter T, Greil GF (2012) Single breath-hold assessment of cardiac function using an accelerated 3D single breath hold acquisition technique—comparison of an intravascular and extravascular contrast agent. J Cardiovasc Magn Reson 31(14):53

    Article  Google Scholar 

  3. Liu J, Spincemaille P, Codella NC, Nguyen TD, Prince MR, Wang Y (2010) Respiratory and cardiac self-gated free-breathing cardiac CINE imaging with multiecho 3D hybrid radial SSFP acquisition. Magn Reson Med 63(5):1230–1237

    Article  PubMed Central  PubMed  Google Scholar 

  4. Lai P, Brau AC, Beatty P, Shankaranarayanan A (2009) Highly-accelerated cardiac cine MR imaging using kat ARC. In: ISMRM 2009, Abstract 766

  5. Lai P, Fung MM, Vasanawala SS, Brau AC (2012) Single breathhold three-dimensional cardiac cine MRI with whole ventricular coverage and retrospective cardiac gating using kat ARC. J Cardiovasc Magn Reson 14(Suppl 1):W69

    Article  PubMed Central  Google Scholar 

  6. Kozerke S, Tsao J, Razavi R, Boesiger P (2004) Accelerating cardiac cine 3D imaging using k-t BLAST. Magn Reson Med 52(1):19–26

    Article  PubMed  Google Scholar 

  7. Lai P, Alley MT, Vasanawala SS, Brau AC (2011) Single-breathhold three-dimensional cardiac cine mri with retrospective cardiac gating using high acceleration kat arc (k- and adaptive t-autocalibrating reconstruction for cartesian sampling. In: ISMRM 2011. Abstract 3378

  8. Lai P, Vasanawala S, Brau AC (2014) Toward robust clinically-practical single-breathhold 3D cardiac cine MRI with high acceleration and rapid online reconstruction. In: ISMRM 2014. Abstract 4379

  9. Lai P, Vasanawala S, Nozaki A et al (2013) Improving k-t auto-calibrating parallel imaging for 3D cardiac cine MRI using prior-reconstruction static tissue estimation and elimination. In: ISMRM 2013. Abstract 128

  10. Rochitte CE, Zzevedo CF, Rosario MA, Siqueira MH, Monsao V, Saranathan M, Foo TK, Filho RK, Cerri GG, Ramires JA (2001) Single-breathold four-dimensional assessment of left ventricular morphological and functional parameters by magnetic resonance imaging using the VAST technique. Open Cardiovasc Med J 5:90–98

    Article  Google Scholar 

  11. Kellman P, McVeigh ER (2005) Image reconstruction in SNR units: a general method for SNR measurement. Magn Reson Med 54(6):1439–1447

    Article  PubMed Central  PubMed  Google Scholar 

  12. Dietrich O, Raya JG, Reeder SB, Reiser MF, Schoenberg SO (2007) Measurement of signal-to-noise ratios in MR images: influence of multichannel coils, parallel imaging, and reconstruction filters. J Magn Reson Imaging 26(2):375–385

    Article  PubMed  Google Scholar 

  13. Wintersperger BJ, Nikolaou K, Dietrich O, Rieber J, Nittka M, Reiser MF, Schoenberg SO (2003) Single breath-hold real-time cine MR imaging improved temporal resolution using generalized autocalibrating partially parallel acquisition (GRAPPA) algorithm. Eur Radiol 13:1931–1936

    Article  PubMed  Google Scholar 

  14. Huber S, Muthupillai R, Mojibian H, Cheong B, Kouwenhoven M, Flamm SD (2008) Rapid assessment of regional and global left ventricular function using three-dimensional k-t BLAST imaging. Magn Reson Imaging 26:727–738

    Article  PubMed  Google Scholar 

  15. Amano Y, Suzuki Y, van Cauteren M (2008) Evaluation of global cardiac functional parameters using single-breath-hold three-dimensional cine steady-state free precession MR imaging with two types of speed-up techniques: comparison with two-dimensional cine imaging. Comput Med Imaging Graph 32(1):61–66

    Article  PubMed  Google Scholar 

  16. Muthurangu V, Noble N, Boubertakh R et al (2006) Single breath-hold 3D cine imaging of the heart: a non-angulated isotrophic acquisition using SENSE on a 32 channel system. Proceedings of 14th annual meeting. In: ISMRM, Seattle 2006, Abstract 300

  17. Maredia N, Kozerke S, Larghat A, Abidin N, Greenwood JP, Boesiger P, Plein S (2008) Measurement of left ventricular dimensions with contrast-enhanced three-dimensional cine imaging facilitated by k-t SENSE. J Cardiovasc Magn Reson 10:27

    Article  PubMed Central  PubMed  Google Scholar 

  18. Wech T, Pickl W, Tran-Gia J, Ritter C, Beer M, Hahn D, Köstler H (2014) Whole—heart cine MRI in a single breath hold—a compressed sensing accelerated 3D acquisition technique for assessment of cardiac function. Rofo 186(1):37–41

    CAS  PubMed  Google Scholar 

  19. Uribe S, Tangchaoren T, Parish V, Wolf I, Razavi R, Greil G, Schaeffter T (2008) Volumetric cardiac quantification by using 3D dual-phase whole-heart MR imaging. Radiology 248:606–614

    Article  PubMed  Google Scholar 

  20. Srinivasan S, Ennis DB (2013) Variable flip angle balanced steady-state free precession for lower SAR or higher contrast cardiac cine imaging. Magn Reson Med 71(3):1035–1043

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI, 53562, USA

    Daniel Jeong, Mark L. Schiebler, Karl K. Vigen & Christopher J. François

  2. Department of Radiology, Moffitt Cancer Center, Tampa, FL, USA

    Daniel Jeong

  3. Global MR Applications and Workflow, GE Healthcare, Menlo Park, CA, USA

    Peng Lai

  4. Global MR Applications and Workflow, GE Healthcare, Madison, WI, USA

    Kang Wang

  5. Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA

    Christopher J. François

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  1. Daniel Jeong
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  2. Mark L. Schiebler
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  3. Peng Lai
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  4. Kang Wang
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  5. Karl K. Vigen
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  6. Christopher J. François
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Correspondence to Christopher J. François.

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Jeong, D., Schiebler, M.L., Lai, P. et al. Single breath hold 3D cardiac cine MRI using kat-ARC: preliminary results at 1.5T. Int J Cardiovasc Imaging 31, 851–857 (2015). https://doi.org/10.1007/s10554-015-0615-0

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  • DOI: https://doi.org/10.1007/s10554-015-0615-0

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