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Evaluation of extracellular volume fraction thresholds corresponding to myocardial late-gadolinium enhancement using cardiac magnetic resonance

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Abstract

To establish extracellular volume fraction (ECV) thresholds corresponding to myocardial lesion detected by late-gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging. Fifty-six patients with myocardial infarction or hypertrophic cardiomyopathy underwent LGE, pre- and post-contrast modified Look-Locker inversion recovery (MOLLI) sequences on a 3-T CMR system. Short-axis MOLLI images generated ECV maps of left ventricular (LV) walls. The LGE areas were semi-automatically determined by different signal threshold techniques. The areas of elevated ECV were measured using ECV thresholds of 28–48 %. The LGE areas were compared with the areas of elevated ECV at the corresponding LV levels. The myocardial areas of LGE and elevated ECVs showed a strong and positive correlation (P < 0.01). The LGE threshold, set at two standard deviations above the mean signal from the remote myocardium, corresponded well with the area of ECV >32 %. When using the full width at half-maximum (FWHM) technique, the LGE area corresponded well with the area of ECV >42 or 44 %. By applying particular ECV thresholds, myocardial ECV maps can define myocardial status equivalent to LGE, and definite ECV thresholds may be useful for the straightforward evaluation of myocardial phenotypes.

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Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Radiology, Anam Hospital College of Medicine, Korea University, Seoul, South Korea

    Sung Ho Hwang

  2. Division of Cardiology, Heart Center, Gangnam Severance Hospital College of Medicine, Yonsei University, Seoul, South Korea

    Eui-Young Choi

  3. Department of Radiology, Gangnam Severance Hospital College of Medicine, Yonsei University, Seoul, South Korea

    Chul Hwan Park & Tae Hoon Kim

  4. Siemens Healthcare, Seoul, Republic of Korea

    Mun Young Paek

  5. Siemens AG Healthcare, Erlangen, Germany

    Andreas Greiser

  6. Department of Radiology, Severance Hospital College of Medicine, Yonsei University, 250 Seongsanno (134 Sinchon-dong), Seodaemun-gu, Seoul, 120-752, South Korea

    Byoung Wook Choi

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  1. Sung Ho Hwang
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  2. Eui-Young Choi
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  3. Chul Hwan Park
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  4. Mun Young Paek
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  5. Andreas Greiser
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  6. Tae Hoon Kim
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  7. Byoung Wook Choi
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Correspondence to Byoung Wook Choi.

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Hwang, S.H., Choi, EY., Park, C.H. et al. Evaluation of extracellular volume fraction thresholds corresponding to myocardial late-gadolinium enhancement using cardiac magnetic resonance. Int J Cardiovasc Imaging 30 (Suppl 2), 137–144 (2014). https://doi.org/10.1007/s10554-014-0489-6

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  • DOI: https://doi.org/10.1007/s10554-014-0489-6

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