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Association of prediagnostic physical activity with survival following breast cancer diagnosis: influence of TP53 mutation status

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Abstract

Purpose

Physical activity both before and after breast cancer diagnosis has been associated with improved survival. However, it is not clear whether this association differs by molecular features of the tumor or by recency of the physical activity to the time of diagnosis.

Methods

We examined the association of prediagnostic physical activity with survival in a cohort of 1,170 women with primary, incident, and histologically confirmed breast cancer, examining tumor molecular subtypes. Cox regression models were used to estimate hazard ratios (HR) and 95 % confidence intervals (95 % CI).

Results

Mean follow-up time was 87.4 months after breast cancer diagnosis; there were 170 deaths identified. Compared with inactive patients (<3 h/week), women with higher average lifetime physical activity (>6 h/week) had reduced risk of all-cause mortality (adjusted HR = 0.61, 95 % CI 0.40–0.95; p trend =0.04). There were no clear differences in the associations for lifetime and more recent physical activity. Lifetime physical activity was also weakly associated with decreased risk of breast cancer-specific mortality. Higher lifetime physical activity was associated with reduced risk of all-cause mortality among women with ER-positive tumors (HR = 0.52, 95 % CI 0.29–0.93) and mutant TP53 tumors (HR = 0.22, 95 % CI 0.06–0.72); however, no statistically significant interactions were observed for ER or TP53 status.

Conclusions

Our study further supports that prediagnostic physical activity improves overall survival following breast cancer and suggests that the associations of prediagnostic physical activity with survival following breast cancer may vary by molecular features of the tumor, particularly ER and TP53 status.

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Acknowledgments

This study would not have been possible without the support of all the study participants and the research staff of the WEB Study. This work was supported in part by the National Institute on Alcohol Abuse and Alcoholism (P50-AA09802), the Department of Defense (DAMD 179616202, DAMD 17030446), and the National Cancer Institute (R01CA 092040).

Conflict of interest

All authors have no conflict of interests.

Author information

Authors and Affiliations

  1. Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, Box 1057, New York, NY, 10029, USA

    Meng-Hua Tao

  2. International Prevention Research Institute, 69130, Ecully, France

    Pierre Hainaut

  3. Biochemistry and Pharmacology Department, “Victor Babes” University of Medicine and Pharmacy, 300041, Timisoara, Romania

    Catalin Marian

  4. Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, 14214, USA

    Jing Nie & Jo L. Freudenheim

  5. Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA

    Christine Ambrosone

  6. Department of Surgery, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA

    Stephen B. Edge

  7. City College of New York, New York, NY, 10031, USA

    Maurizio Trevisan

  8. Physical Activity and Health Branch, Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA

    Joan Dorn

  9. Ohio State University Cancer Center, The Ohio State University, Columbus, OH, 43210, USA

    Peter G. Shields

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  1. Meng-Hua Tao
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Correspondence to Meng-Hua Tao.

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Tao, MH., Hainaut, P., Marian, C. et al. Association of prediagnostic physical activity with survival following breast cancer diagnosis: influence of TP53 mutation status. Cancer Causes Control 24, 2177–2186 (2013). https://doi.org/10.1007/s10552-013-0294-x

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  • DOI: https://doi.org/10.1007/s10552-013-0294-x

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