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Associations between BMI, energy intake, energy expenditure, VDR genotype and colon and rectal cancers (United States)

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Abstract

Components of energy balance are important elements associated with colorectal cancer risk. In this study we examine the association between VDR genotypes, BMI, physical activity, and energy intake and risk of colorectal cancer. Data from a population-based case–control study of colon (1174 cases and 1174 controls) and rectal (785 cases and 1000 controls) cancer was used to evaluate the associations. The Bsm1, polyA, and Fok1 VDR polymorphisms were evaluated. For colon cancer, those who are obese were at greater risk of colon cancer if they had the SS or BB (OR=3.50; 95 CI=1.75–7.03; p interaction 0.03) or ff (OR=2.62; 95 CI=1.15–5.99; p interaction 0.12/) VDR genotypes. On the other hand, those who were least physically active were at greater risk of colon cancer if they had theff VDR genotype (OR=3.46; 95 CI=1.58–7.58; p interaction 0.05. The association between energy intake and colon cancer appears to be driven more by energy intake than Bsm1 or polyA VDR genotypes, although there was a significant interaction between the Fok1 VDR polymorphism and energy intake and risk of both colon and rectal cancer (p interaction 0.01 for colon and 0.04 for rectal). These data suggest a relationship between VDR genotype and factors related to energy balance in modifying colorectal cancer risk.

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Abbreviations

VDR:

vitamin D receptor

RFLP:

restriction fragment length polymorphisms

3′ UTR I′:

3 untranslated region

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Authors and Affiliations

  1. Health Research Center, University of Utah, Salt Lake City, Utah, 84108

    Martha L. Slattery, Maureen Murtaugh, Khe Ni Ma & Roger Wolff

  2. Department of Family and Health Research Center, Preventive Medicine, 375 Chipeta Way, Suite A, Salt Lake City, UT, 84/08, US

    Martha L. Slattery

  3. Kaiser Permanente Medical Research Program, Oakland, California

    Bette Caan

  4. Department of Surgical Pathology, University of Utah, Salt Lake City, Utah

    Wade Samowitz

Authors
  1. Martha L. Slattery
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  2. Maureen Murtaugh
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  3. Bette Caan
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  4. Khe Ni Ma
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  5. Roger Wolff
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  6. Wade Samowitz
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Correspondence to Martha L. Slattery.

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Slattery, M.L., Murtaugh, M., Caan, B. et al. Associations between BMI, energy intake, energy expenditure, VDR genotype and colon and rectal cancers (United States). Cancer Causes Control 15, 863–872 (2004). https://doi.org/10.1007/s10552-004-1048-6

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  • DOI: https://doi.org/10.1007/s10552-004-1048-6

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