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Surveillance for second breast cancer events in women with a personal history of breast cancer using breast MRI: a systematic review and meta-analysis

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Abstract

Purpose

Women with personal history of breast cancer (PHBC) are currently recommended to receive annual mammography for surveillance of breast cancer recurrence or new primary. However, given issues in accuracy with mammography, there is a need for evolving evidence-based surveillance recommendations with supplemental imaging. In this systematic review, we compiled and compared existing studies that describe the test performance of surveillance breast MRI among women with PHBC.

Methods

We searched PubMed and EMBASE using MeSH terms for studies (2000–2019) that described the diagnostic characteristics of breast MRI in women with PHBC. Search results were reviewed and included based on PICOTS criteria; quality of included articles was assessed using QUADAS-2. Meta-analysis of single proportions was conducted for diagnostic characteristics of breast MRI, including tests of heterogeneity.

Results

Our review included 11 articles in which unique cohorts were studied, comprised of a total of 8338 women with PHBC and 12,335 breast MRI done for the purpose of surveillance. We predict intervals (PI) for cancer detection rate per 1000 examinations (PI 9–15; I2 = 10%), recall rate (PI 5–31%; I2 = 97%), sensitivity (PI 58–95%; I2 = 47%), specificity (PI 76–97%; I2 = 97%), and PPV3 (PI 16–40%; I2 = 44%).

Conclusions

Studies addressing performance of breast MRI are variable and limited in population-based studies. The summary of evidence to date is insufficient to recommend for or against use of breast MRI for surveillance among women with PHBC.

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Abbreviations

PHBC:

Personal history of breast cancer

BCSC:

Breast Cancer Surveillance Consortium

MRI:

Magnetic resonance imaging

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Funding

This work was supported through a Patient-Centered Outcomes Research Institute (PCORI) Project Program Award (CE-1304-6656-Comparative effectiveness of surveillance imaging modalities in breast cancer survivors). The design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication is solely the responsibility of the authors and does not necessarily represent the official views of the Patient-Centered Outcomes Research Institute. This publication was supported by grant number T32 CA094880 from the National Institute of Health. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NCI, NIH.

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Authors and Affiliations

  1. Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA

    Cameron B. Haas

  2. Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave. Ste 1600, Seattle, WA, 98101, USA

    Cameron B. Haas, Mary Bush, Dianne Johnson & Karen J. Wernli

  3. Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Larissa Nekhlyudov

  4. Department of Radiology, School of Medicine, University of Washington, Seattle, WA, USA

    Janie M. Lee, Sara H. Javid & Jennifer Specht

  5. Swedish Medical Center, Seattle, WA, USA

    Timothy Gleason

  6. Bellingham Regional Beast Center, Bellingham, WA, USA

    Cary Kaufman

  7. Kaiser Permanente Washington, Bellevue, WA, USA

    Sean Stitham

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  1. Cameron B. Haas
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Corresponding author

Correspondence to Cameron B. Haas.

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Authors CBH, LN, JML, SHJ, MB, DJ, CK, JS, SS, and KJW declare that they have no conflicts of interest. Dr Gleason owns stock in Radia Inc.

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Haas, C.B., Nekhlyudov, L., Lee, J.M. et al. Surveillance for second breast cancer events in women with a personal history of breast cancer using breast MRI: a systematic review and meta-analysis. Breast Cancer Res Treat 181, 255–268 (2020). https://doi.org/10.1007/s10549-020-05637-y

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