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The association between polymorphisms in the leptin receptor gene and risk of breast cancer: a systematic review and pooled analysis

  • Epidemiology
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Abstract

Many epidemiological studies have found that leptin correlates to body fat extent and breast cancer. Leptin exerts its physiological action through the leptin receptor (LEPR). However, published data on the association between LEPR alleles and breast cancer occurrence have led to in contradictory results. A total of 10 studies were identified to the meta-analysis, including 4,644 cases and 5,485 controls for LEPR rs1137101 polymorphism, 5 studies with 2,759 cases and 4,464 controls for rs1137100 polymorphism, and 2 studies for rs8051542, rs8051542, and rs8051542 polymorphisms. The pooled odds ratios (OR) with 95 % confidence intervals (CI) for breast cancer risk associated with LEPR genotypes were estimated. Elevated breast cancer risk was associated with LEPR rs1137101 polymorphism when all studies were pooled in the meta-analysis (allele contrast model: OR = 0.71, 95 % CI = 0.551–0.997). In the stratified analysis by ethnicity, significantly increased risks were also found among Asians for allele contrast model (OR 0.414, 95 % CI 0.312–0.550) and dominant model (OR 0.537, 95 % CI 0.370–0.781); for Africans, significantly increased risks were also found for allele contrast model (OR 0.716, 95 % CI 0.595–0.861), homozygote codominant (OR 0.537, 95 % CI 0.370–0.781) and dominant model (OR 1.595, 95 % CI 1.207–2.108). And significantly elevated breast cancer risk was associated with LEPR rs1137100 polymorphism for allele contrast (OR = 0.666, 95 % CI = 0.603–0.720) and homozygote codominant models (OR = 0.344, 95 % CI = 0.282–0.421). For LEPR rs8179183, rs4655537, and rs3762274 polymorphisms, no significant associations were detected in all comparison models. This pooled analysis suggested that rs1137101 and rs1137100 polymorphisms were significantly correlated with breast cancer risk and the A allele of LEPR rs1137101 variant and the G allele of LEPR rs1137100 variant were low-penetrant risk factors for developing breast cancer. Further, no significant associations existed between LEPR rs8179183, rs4655537, and rs3762274 polymorphisms and risk of breast cancer.

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Conflict of interest

The authors are fully responsible for all content and editorial decisions, and they have not received any financial support or other form of remuneration related to the development of this article.

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Authors and Affiliations

  1. Department of Oncology, Kunshan People’s Hospital Affiliated to Jiangsu University, No. 91, Qianjin Road, Kunshan, 215300, Jiangsu, China

    Li-qiang Wang & Min-Bin Chen

  2. Department of General Surgery, Wuxi People’s Hospital Affiliated to Nanjing Medical University, No. 299, Qingyang Road, Wuxi, 214023, Jiangsu, China

    Wei Shen, Pei-Hua Lu & Guo-Qing Tao

  3. Department of Endocrinology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, No. 299, Qingyang Road, Wuxi, 214023, Jiangsu, China

    Lan Xu

  4. Department of Cardiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, Jiangsu, China

    Ting Gong

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  1. Li-qiang Wang
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  2. Wei Shen
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  3. Lan Xu
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  4. Min-Bin Chen
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Correspondence to Pei-Hua Lu or Guo-Qing Tao.

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Wang, Lq., Shen, W., Xu, L. et al. The association between polymorphisms in the leptin receptor gene and risk of breast cancer: a systematic review and pooled analysis. Breast Cancer Res Treat 136, 231–239 (2012). https://doi.org/10.1007/s10549-012-2228-9

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  • DOI: https://doi.org/10.1007/s10549-012-2228-9

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