Abstract
Background
The CYP1B1 gene is a polymorphic member of the P450 gene family and is considered to be a candidate gene for cancers of various types.
Objective
We inquired whether four SNPs in the CYP1B1 gene, alone or in combination, might be associated with breast cancer risk in Poland.
Methods
We genotyped 2017 cases of breast cancer and 876 controls, for four SNPs in the CYP1B1 gene. Genotype and haplotype frequencies were compared in cases and controls.
Results
In combinations of the R48G, A119S and L432V SNPs, four of the eight CYP1B1 haplotypes were more common in controls than in cases and each of these appeared to have a significant protective effect. A large reduction in risk was observed for women who were homozygous for one of these four haplotypes (OR = 0.2; 95%; CI = 0.05–0.5; P = 0.001) compared to women who were homozygous for the most common haplotype. In contrast, women who were homozygous for the GTC haplotype were at increased risk (OR = 1.5; 95%; CI = 1.0–2.1; P = 0.03) compared to women with the most common haplotype.
Conclusions
The CYP1B1 gene appears to influence breast cancer susceptibility in Poland.
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References
Hayes CL, Spink DC, Spink BC et al (1996) 17β-Estradiol hydroxylation catalysed by human cytochrome P450 1B1. Proc Natl Acad Sci USA 93:9776–9781
Spink DC, Eugster H, Lincoln II DW et al (1992) 17β-Estradiol hydroxylation catalysed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8, -tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. Arch Biochem Biophys 293:342–348
Spink DC, Hayes CL, Young NR et al (1994) The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: evidence for induction of a novel 17β-estradiol 4-hydroxylase. J Steroid Biochem Mol Biol 51:251–258
Han X, Liehr JG (1994) DNA single-strand breaks in kidneys of Syrian hamsters treated with steroidal estrogens:hormone-induced free radical damage preceding renal malignancy. Carcinogenesis 15:997–1000
Chakravarti D, Mailander PC, Li KM et al (2001) Evidence that a burst of DNA depurination in SENCAR mouse skin induces error-prone repair and forms mutations in the H-ras gene. Oncogene 20:7945–7953
Service RF (1998) New role for estrogen in cancer. Science 279:1631–1633
Jan ST, Devanesan PD, Stack DE et al (1998) Metabolic activation and formation of DNA adducts of hexestrol, a synthetic nonsteroidal carcinogenic estrogen. Chem Res Toxicol 11:412–419
Watanabe J, Shimada T, Gillam EM et al (2000) Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer. Pharmacogenetic 10:25–33
Gotoh O, Tagashira Y, Lizuka T et al (1983) Structural characteristic of cytochrome P450; possible location of the heme-binding cysteine in determined amino acid sequence. J Biochem 93:807–817
Hanna IH, Dawling S, Roodi N, et al (2000) Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity. Cancer Res 60:3440–3444
Shimada T, Hayes CL, Yamazaki H et al (1996) Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. Cancer Res 56:2979–2984
Shimada T, Watanabe J, Kawajiri K et al (1999) Catalytic properties of polymorphic human cytochrome P4501B1 variants. Carcinogenesis 20:1607–1613
Rylander-Rudqvist T, Wedren S, Granath F et al (2003) Cytochrome P450 1B1 gene polymorphisms and post menopausal breast cancer risk. Carcinogenesis 24:1533–1539
Bailey LR, Roodi N, Dupont WD et al (1998) Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer. Cancer Res 58:5038–5041
De Vivo I, Hankinson SE, Li L et al (2002) Association of CYP1B1 Polymorphisms and Breast Cancer Risk. Cancer Epidemiol Biomarkers Prev 11:489–492
Aksan H, Chen Y, Whittemore AS et al (2004) A family –based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk. Breast Cancer Res Treat 85:121–131
Kocabas NA, Sardas S, Cholerton S et al (2002) Cytochrome P450 and catechol O-methyltransferase (COMT) genetic polymorphism and breast cancer susceptibility in a Turkish population. Arch Toxicol 76:643–649
Zheng W, Xie DW, Jin F et al (2000) Genetic Polymorphism of Cytochrome P450–1B1 and Risk of Breast Cancer. Cancer Epidemiol Biomarkers Prev 9:147–150
Schaid DJ, Rowland CM, Tines DE et al (2002) Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 70:425–434
Chang BL, Zheng SL, Isaacs SD et al (2003) Polymorphisms in the CYP1B1 gene are associated with increased risk of prostate cancer. British Journal of Cancer 89:1524–1529
Cicek MS, Liu X, Carey G et al (2005) Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness. Cancer Epidemiol Biomarkers Prev 14:2173–2177
Wen W, Cai Q, Shu XO et al (2005) Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and breast cancer risk in Chinese women: results from the Shanghai breast cancer study and meta-analysis. Cancer Epidemiol Biomarkers Prev 14:329–35
Gallicchio L, Berndt SI, McSorley MA et al (2006) Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease. BMC Cancer 6:173
Acknowledgments
We would like to acknowledge the contributions of M. Bębenek, J. Bręborowicz, M. Chosia, B. Czeszyńska, R. Czajka, B. Dębniak, W. Domagała, I. Dziuba, M. Foszczyńska-Kłoda, L.Fudali, S. Gozdecka-Grodecka, S. Góźdź, E. Grzybowska, K. Gugała, O. Haus, H. Janiszewska, A. Karczewska, J. Kładny, R. Kordek, A. Kozak, B. Kozak-Klonowska, W. Kozłowski., K.Lamperska, D. Lange, A. Lenczewski, A. Mackiewicz, E. Marczyk, B.Mąka, T. Mierzwa, M. Morawiec, B. Musiatowicz, J. Mituś, S. Niepsuj, M. Posmyk, A. Rozmiarek, J. Ryś, J. Sir, J. Skręt, M. Stawicka, D.Sorokin, J.Sygut, C.Szczylik, M. Szwiec, D. Surdyka, M. Uciński, K. Urbański, P. Wandzel, B.Waśko, A. Witek, R.Wiśniowski, A. Wojnar, J. Woytoń, O. Zambrano in collection of patients and controls.
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Matyjasik, J., Cybulski, C., Masojć, B. et al. CYP1B1 and predisposition to breast cancer in Poland. Breast Cancer Res Treat 106, 383–388 (2007). https://doi.org/10.1007/s10549-007-9500-4
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DOI: https://doi.org/10.1007/s10549-007-9500-4