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CDKN2A-positive breast cancers in young women from Poland

  • EPIDEMIOLOGY
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Abstract

Purpose: To investigate the contribution of CDKN2A A148T common variant to early-onset breast cancer in Poland, and to establish the characteristic features of these cancers.

Experimental design: We studied 3,069 women diagnosed with breast cancer under the age of 51 and 3,493 population controls. CDKN2A variant were detected using RFLP-PCR and confirmed by genomic sequencing. Clinical and pathological features of CDKN2A-positive cases and CDKN2A-negative cases were compared.

Results: A148T variant was identified in 157 of 3,069 women with breast cancer (5.1%). Overall, the odds ratio for early-onset breast cancer, given a CDKN2A variant was 1.4 (95% CI 1.075–1.725; = 0.012). Breast tumors in women with the CDKN2A variant were more commonly intraductal cancers (DCIS) with micro-invasion (14.8% vs. 8.5%; = 0.035). Carriers and non-carriers were similar with respect to tumor size, laterality, multicentricity, nodal status, family history and estrogen-receptor status.

Conclusion: The CDKN2A A148T variant seems to contribute to early-onset breast cancer in Poland. Breast tumors which arise in carriers of A148T variant appear to be similar to those of breast cancers in the population at large.

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Acknowledgments

We thank the following people who helped in this study: W. Domagała, M. Chosia, M. Uciński, E. Grzybowska, D. Lange, B. Mika, A. Mackiewicz, A. Karczewska, J. Breborowicz, K. Lamperska, M. Stawicka, S. Gozdecka-Grodecka, M. Bębenek, D. Sorokin, A. Wojnar, O. Haus, J. Sir, T. Mierzwa, S. Niepsuj, K. Gugała, S. Goźdź, J. Sygut, B. Kozak-Klonowska, B. Musiatowicz, M. Posmyk, R. Kordek, M. Morawiec, O. Zambrano, B. Waśko, L. Fudali, D. Surdyka, K. Urbański, J. Mituś, J. Ryś, M. Szwiec, A. Rozmiarek, I. Dziuba, P. Wandzel, R. Wiśniowski, C. Szczylik, A. Kozak, A. Kozłowski, R. Czajka, B. Czeszyńska, B. Dębniak, G. Brębowicz, B. Kalużewski, A. Witek, A. Skret, A. Lenczewski, J. Wonton and R. Gibaszek.

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Correspondence to Tadeusz Dębniak.

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Dębniak, T., Cybulski, C., Górski, B. et al. CDKN2A-positive breast cancers in young women from Poland. Breast Cancer Res Treat 103, 355–359 (2007). https://doi.org/10.1007/s10549-006-9382-x

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  • DOI: https://doi.org/10.1007/s10549-006-9382-x

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