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Dynamic Brain Activation Patterns for Face Recognition: A Magnetoencephalography Study

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Summary:

The present study used magnetoencephalography (MEG) to investigate the spatiotemporal profile of neurophysiological activity associated with recognition of recently encountered human faces in seventeen healthy right-handed adults. Activity sources modeled as instantaneous equivalent current dipoles were found in ventral occipito-temporal regions during the early stages of stimulus processing and in lateral temporal cortices during later stages. Hemispheric asymmetries in regional activity were restricted to ventral occipitotemporal areas. The magnitude of magnetic flux originating in these regions was greater in the right hemisphere during the first 350 ms post-stimulus onset. In addition, the duration of neurophysiological activity was greater in the right hemisphere after 600 ms post-stimulus onset. The results indicate right hemisphere predominance in the degree of engagement of neurophysiological processes involved in both the pre- and post-recognition phases of face processing.

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References

  • Allison, T., Ginter, H., McCarthy, G., Nobre, A.C., Puce, A., Luby, M. and Spencer, D.D. Face recognition in human extrastriate cortex. J. Neurophysiol., 1994, 71(2): 821–825.

    PubMed  Google Scholar 

  • Benton, A.L. The neuropsychology of facial recognition. Am. Psychol., 1980, 35(2): 176–186.

    Article  PubMed  Google Scholar 

  • Bodamer, J. Die Prosop-Agnosie [Prosopagnosia]. Archiv fur Psychiatrie und nervenkrankheiten, 1947, 179: 6–53.

    Article  Google Scholar 

  • Bruce, C., Desimone, R. and Gross, C.G. Visual properties of neurons in a polysensory area in superior temporal sulcus of the macaque. J. Neurophysiol., 1981, 46(2): 369–384.

    PubMed  Google Scholar 

  • Breier, J.I., Simos, P.G., Zouridakis, G., Wheless, J.W., Willmore, L.J., Constantinou, J.E., Maggio, W.W. and Papanicolaou, A.C. Language dominance determined by magnetic source imaging: a comparison with the Wada procedure. Neurology, 1999, 53(5): 938–945.

    PubMed  Google Scholar 

  • Breier, J.I., Simos, P.G., Zouridakis, G. and Papanicolaou, A.C. Lateralization of activity associated with language function using magnetoencephalography: a reliability study. J. Clin. Neurophysiol., 2000, 17(5): 503–510.

    Article  PubMed  Google Scholar 

  • Breier, J.I., Simos, P.G., Wheless, J.W., Constantinou, J.E., Baumgartner, J.E., Venkataraman, V. and Papanicolaou, A.C. Language dominance in children as determined by magnetic source imaging and the intracarotid amobarbital procedure: a comparison. J. Child Neurol., 2001, 16(2): 124–130.

    PubMed  Google Scholar 

  • Castillo, E.M., Simos, P.G., Venkataraman, V., Breier, J.I., Wheless, J.W. and Papanicolaou, A.C. Mapping of expressive language cortex using magnetic source imaging. Neurocase., 2001, 7(5): 419–422.

    Article  PubMed  Google Scholar 

  • Clark, V.P., Keil, K., Maisog, J.M., Courtney, S., Ungerleider, L.G. and Haxby, J.V. Functional magnetic resonance imaging of human visual cortex during face matching: a comparison with positron emission tomography. Neuroimage, 1996, 4(1): 1–15.

    Article  PubMed  Google Scholar 

  • Courtney, S.M., Ungerleider, L.G., Keil, K. and Haxby, J.V. Object and spatial visual working memory activate separate neural systems in human cortex. Cereb. Cortex, 1996, 6(1): 39–49.

    PubMed  Google Scholar 

  • Damasio, A.R., Damasio, H. and Van Hoesen, G.W. Prosopagnosia: anatomic basis and behavioral mechanisms. Neurology, 1982, 32(4): 331–341.

    PubMed  Google Scholar 

  • De Renzi, E. Prosopagnosia in two patients with CT scan evidence of damage confined to the right hemisphere. Neuropsychologia, 1986, 24(3): 385–389.

    Article  PubMed  Google Scholar 

  • Dolan, R.J., Fletcher, P., Morris, J., Kapur, N., Deakin, J.F. and Frith, C.D. Neural activation during covert processing of positive emotional facial expressions. Neuroimage, 1996, 4(3 Pt 1): 194–200.

    Article  PubMed  Google Scholar 

  • Farah, M.J. and Aguirre, G.K. Imaging visual recognition: PET and fMRI studies of the functional anatomy of human visual recognition. Trends Cogn. Sci., 1999, 3(5): 179–186.

    Article  PubMed  Google Scholar 

  • Gauthier, I., Tarr, M.J., Moylan, J., Skudlarski, P., Gore, J.C. and Anderson, A.W. The fusiform “face area” is part of a network that processes faces at the individual level. J. Cogn. Neurosci., 2000, 12(3): 495–504.

    Article  PubMed  Google Scholar 

  • Halgren, E., Raij, T., Marinkovic, K., Jousmaki, V. and Hari, R. Cognitive response profile of the human fusiform face area as determined by MEG. Cereb. Cortex, 2000, 10(1): 69–81.

    Article  PubMed  Google Scholar 

  • Hamsher, K., Levin, H.S. and Benton, A.L. Facial recognition in patients with focal brain lesions. Arch. Neurol., 1979, 36: 837–839.

    PubMed  Google Scholar 

  • Haxby, J.V., Horwitz, B., Ungerleider, L.G., Maisog, J.M., Pietrini, P. and Grady, C.L. The functional organization of human extrastriate cortex: a PET-rCBF study of selective attention to faces and locations. J. Neurosci., 1994, 14: 6336–6353.

    PubMed  Google Scholar 

  • Hecaen, H. and Angelergues, R. Agnosia for faces (prosopagnosia). Arch. Neurol., 1962, 7: 92–100.

    PubMed  Google Scholar 

  • Hillebrand, A. and Barnes, G.R. The use of anatomical constraints with MEG beamformers. Neuroimage, 2003, 20(4): 2302–2313.

    Article  PubMed  Google Scholar 

  • Hoshiyama, M., Kakigi, R., Watanabe, S., Miki, K. and Takeshima, Y. Neuroscience Research, 2003, 46(4): 435–442.

    Article  PubMed  Google Scholar 

  • Kanwisher, N., McDermott, J. and Chun, M.M. The fusiform face area: a module in human extrastriate cortex specialized for face perception. J. Neurosci., 1997, 17(11): 4302–4311.

    PubMed  Google Scholar 

  • Kendrick, K.M., da Costa, A.P., Leigh, A.E., Hinton, M.R. and Peirce, J.W. Sheep don't forget a face. Nature, 2001, 414(6860): 165–166.

    Article  PubMed  Google Scholar 

  • Landis, T., Cummings, J.L., Christen, L., Bogen, J.E. and Imhof, H.G. Are unilateral right posterior cerebral lesions sufficient to cause prosopagnosia? Clinical and radiological findings in six additional patients. Cortex, 1986, 22(2): 243–252.

    PubMed  Google Scholar 

  • Linkenkaer-Hansen, K., Palva, J.M., Sams, M., Hietanen, J.K., Aronen, H.J. and Ilmoniemi R.J. Neurosicence Letters, 1998, 253(3): 147–150.

    Article  Google Scholar 

  • Liu, J., Harris, A. and Kanwisher, N. Stages of processing in face perception: an MEG study. Nature Neuroscience, 2002, 5(9): 910–916.

    Article  PubMed  Google Scholar 

  • Maestu, F., Fernandez, A., Simos, P.G., Gil-Gregorio, P., Amo, C., Rodriguez, R., Arrazola, J. and Ortiz, T. Spatio-temporal patterns of brain magnetic activity during a memory task in Alzheimer's disease. Neuroreport, 2001, 12(18): 3917–3922.

    Article  PubMed  Google Scholar 

  • Maestu, F., Ortiz, T., Fernandez, A., Amo, C., Martin, P., Fernandez, S. and Sola, R.G. Spanish language mapping using MEG: a validation study. Neuroimage, 2002, 17(3): 1579–1586.

    Article  PubMed  Google Scholar 

  • Martinez, A.M. and Benavente, R. The AR Face Database (No. 24): CVC Technical Report, 1998.

  • Meadows, J.C. The anatomical basis of prosopagnosia. J. Neurol. Neurosurg. Psychiatry, 1974, 37(5): 489–501.

    PubMed  Google Scholar 

  • Oldfield, R.C. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia, 1971, 9(1): 97–113.

    Article  PubMed  Google Scholar 

  • Papanicolaou, A.C., Simos, P.G., Castillo, E.M., Breier, J.L, Sarkari, S., Pataraia, E., Billingsley, R.L., Buchanan, S., Wheless, J., Maggio, V. and Maggio, W.W. Magnetocephalography: a noninvasive alternative to the Wada procedure. J. Neurosurg., 2004, 100(5): 867–876.

    PubMed  Google Scholar 

  • Perrett, D.I., Rolls, E.T. and Caan, W. Visual neurons responsive to faces in the monkey temporal cortex. Exp. Brain Res., 1982, 47(3): 329–342.

    Article  PubMed  Google Scholar 

  • Perrett, D.I., Hietanen, J.K., Oram, M.W. and Benson, P.J. Organization and functions of cells responsive to faces in the temporal cortex. Philos. Trans. R. Soc. Lond. B. Biol. Sci., 1992, 335(1273): 23–30.

    PubMed  Google Scholar 

  • Puce, A., Allison, T., Asgari, M., Gore, J.C. and McCarthy, G. Differential sensitivity of human visual cortex to faces, letterstrings, and textures: a functional magnetic resonance imaging study. J. Neurosci., 1996, 16(16): 5205–5215.

    PubMed  Google Scholar 

  • Rolls, E.T. Neurophysiological mechanisms underlying face processing within and beyond the temporal cortical visual areas. Philos. Trans. R. Soc. Lond. B. Biol. Sci., 1992, 335(1273): 11–20.

    PubMed  Google Scholar 

  • Sams, M., Hietanen, J.K., Hari, R., Ilmoniemi, R.J. and Lounasmaa, O.V. Face-specific responses from the human inferior occipito-temporal cortex. Neuroscience, 1997, 77(1): 49–55.

    Article  PubMed  Google Scholar 

  • Sarvas, J. Basic mathematical and electromagnetic concepts of the biomagnetic inverse problem. Phys. Med. Biol., 1987, 32(1): 11–22.

    Article  PubMed  Google Scholar 

  • Sergent, J. and Signoret, J.L. Varieties of functional deficits in prosopagnosia. Cereb. Cortex, 1992, 2(5): 375–388.

    PubMed  Google Scholar 

  • Simos, P.G., Breier, J.I., Zouridakis, G. and Papanicolaou, A.C. Assessment of functional cerebral laterality for language using magnetoencephalography. J. Clin. Neurophysiol., 1998, 15(4): 364–372.

    Article  PubMed  Google Scholar 

  • Simos, P.G., Breier, J.I., Maggio, W.W., Gormley, W.B., Zouridakis, G., Willmore, L.J., Wheless, J.W., Constantinou, J.E. and Papanicolaou, A.C. Atypical temporal lobe language representation: MEG and intraoperative stimulation mapping correlation. Neuroreport, 1999, 10(1): 139–142.

    PubMed  Google Scholar 

  • Simos, P.G., Breier, J.I., Wheless, J.W., Maggio, W.W., Fletcher, J.M., Castillo, E.M. and Papanicolaou, A.C.. Brain mechanisms for reading: the role of the superior temporal gyrus in word and pseudoword naming. Neuroreport, 2000, 11(11): 2443–2447.

    PubMed  Google Scholar 

  • Simos, P.G., Breier, J.I., Fletcher, J.M., Foorman, B.R., Castillo, E.M. and Papanicolaou, A.C. Brain mechanisms for reading words and pseudowords: an integrated approach. Cereb. Cortex, 2002, 12(3): 297–305.

    Article  PubMed  Google Scholar 

  • Swithenby, S.J., Bailey, A.J., Brautigam, S., Josephs, O.E., Jousmaki, V. and Tesche, C.D. Neural processing of human faces: a magnetoencephalographic study. Exp. Brain Res., 1998, 118(4): 501–510.

    Article  PubMed  Google Scholar 

  • Szymanski, M.D., Perry, D.W., Gage, N.M., Rowley, H.A., Walker, J., Berger, M.S. and Roberts, T.P. Magnetic source imaging of late evoked field responses to vowels: toward an assessment of hemispheric dominance for language. J. Neurosurg., 2001, 94(3): 445–453.

    PubMed  Google Scholar 

  • Valaki, C.E., Maestu, F., Simos, P.G., Zhang, W., Fernandez, A., Amo, C.M., Ortiz, T.M. and Papanicolaou, A.C. Cortical organization for receptive language functions in Chinese, English, and Spanish: a cross-linguistic MEG study. Neuropsychologia., 2004, 42(7): 967–979.

    Article  PubMed  Google Scholar 

  • Watanabe, S., Kakigi, R., Koyama, S. and Kirino, E. Human face perception traced by magneto- and electro-encephalography. Brain Res. Cogn. Brain Res., 1999, 8(2): 125–142.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, University of Alabama, Birmingham, USA

    Dongwook Lee, Stephen M. Sawrie, Roy C. Martin & Robert C. Knowlton

  2. Department of Psychology, University of Alabama, Birmingham, USA

    Dongwook Lee

  3. Department of Psychology, University of Crete, Greece

    Panagiotis Simos

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  1. Dongwook Lee
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  2. Panagiotis Simos
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  5. Robert C. Knowlton
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Correspondence to Dongwook Lee.

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This research was supported in part by a grant from Epilepsy Foundation of America to D. Lee.

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Lee, D., Simos, P., Sawrie, S. et al. Dynamic Brain Activation Patterns for Face Recognition: A Magnetoencephalography Study. Brain Topogr 18, 19–26 (2005). https://doi.org/10.1007/s10548-005-7897-9

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