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In–vivo characterization of left–ventricle pressure–volume telemetry system in swine model

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Abstract

We present in-vivo study related to the use of our implantable RF telemetry system for pressure-volume (PV) cardiac monitoring in a animal subject. We implant a commercial MEMS PV sensor into the subject’s heart left-ventricle (LV), while the telemetry system is implanted outside of the heart and connected to the sensor with a 7-microwires tether. The RF telemetry system is suitable for commercial application in medium sized subjects, its total volume of 2.475cm3 and a weight of 4.0g. Our designed system is 58 % smaller in volume, 44 % in weight and has a 55 % reduction in sampling power over the last reported research in PV telemetry. In-vivo data was captured in both an acute and a freely moving setting over a 24 hour period. We experimentally demonstrated viability of the methodology that includes the surgical procedure and real-time monitoring of the in-vivo data in a freely moving subject. Further improvements in catheter design will improve the data quality and safety of the subject. This real–time implantable technology allows for researchers to quantify cardiac pathologies by extracting real–time pressure-volume loops, wirelessly from within freely moving subjects.

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Acknowledgments

The authors would like to express their sincere gratitude to Transonic Scisense Inc., NSERC, OCE, CFI and CMC Microsystems for supporting our research and for providing the design technology.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering at Western University, London, ON, Canada

    Kyle Fricke & Robert Sobot

  2. ENSEA/University Cergy-Pontoise/CNRS, Pontoise, France

    Robert Sobot

  3. Animal Care and Veterinary Services, Western University, London, ON, Canada

    Alexander El-Warrak, Heather Cadieux-Pitre & Tracy Hill

  4. Transonic Scisense Inc., London, ON, Canada

    Filip Konecny & Chad Hodgson

Authors
  1. Kyle Fricke
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  2. Filip Konecny
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  3. Alexander El-Warrak
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  4. Chad Hodgson
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  5. Heather Cadieux-Pitre
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  6. Tracy Hill
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  7. Robert Sobot
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Correspondence to Kyle Fricke.

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Fricke, K., Konecny, F., El-Warrak, A. et al. In–vivo characterization of left–ventricle pressure–volume telemetry system in swine model. Biomed Microdevices 18, 75 (2016). https://doi.org/10.1007/s10544-016-0094-7

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  • DOI: https://doi.org/10.1007/s10544-016-0094-7

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