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Paclitaxel-eluting nanofiber-covered self-expanding nonvascular stent for palliative chemotherapy of gastrointestinal cancer and its related stenosis

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Abstract

Self-expanding non-vascular metal stents (SEMS) is now a choice of treatment for tumor-induced obstructive symptoms of gastrointestinal tract. But in-growing tumor causes re-stenosis. Here, we studied a paclitaxel-eluting nanofiber-covered stent for palliative chemotherapy of gastrointestinal cancer and its related stenosis. In vivo and in vitro feasibility of nanofiber-covered nonvascular stent was evaluated in this study. Nanofiber-covered stent released paclitaxel (PTX) in controlled manner for 30 days. PTX-NFM significantly inhibited the growth of CT-26 colon cancer in comparison with PTX injection. PTX maintained higher tumor concentrations over 1.0 μg/ml for more than 14 days without systemic exposure. TUNEL and H&E staining proved locally concentrated PTX induced the higher apoptosis than PTX injection. In this way, PTX-eluting nanofiber-covered stent possibly inhibits in-growth of cancer and extends patency of stent. Clinical feasibility of PTX-eluting nanofiber nonvascular stent for cholangiocarcinoma and gastrointestinal cancers will be investigated in further studies.

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Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (2014R1A2A2A04006562), and supported by research grant (INHA-47278-01) from INHA UNIVERSITY.

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Authors and Affiliations

  1. Utah-Inha DDS and Advanced Therapeutics Research Center, Incheon, 406-840, Republic of Korea

    Se-Yoon Kim, Mina Kim, Don-Haeng Lee & Su-Geun Yang

  2. Department of New Drug Development and NCEED, School of Medicine, Inha University, Incheon, 400-712, Republic of Korea

    Min-kyoung Kim, Haneul Lee & Don-Haeng Lee

  3. Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University, Seoul, 135-720, Republic of Korea

    Dong Ki Lee

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  1. Se-Yoon Kim
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  2. Mina Kim
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  3. Min-kyoung Kim
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  4. Haneul Lee
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  5. Dong Ki Lee
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  6. Don-Haeng Lee
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Correspondence to Su-Geun Yang.

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Kim, SY., Kim, M., Kim, Mk. et al. Paclitaxel-eluting nanofiber-covered self-expanding nonvascular stent for palliative chemotherapy of gastrointestinal cancer and its related stenosis. Biomed Microdevices 16, 897–904 (2014). https://doi.org/10.1007/s10544-014-9894-9

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