Abstract
This paper presents an ultra-thin and flexible polymer-based capacitive pressure sensor for intraocular pressure (IOP) monitoring in a mouse eye. Due to the size limitation of the anterior chamber in the mouse eye, a volume of approximately 700 × 700 × 150 μm3 on a small substrate is available for the MEMS capacitive pressure sensor. Moreover, the sensor would ideally be easily injectable into place. Further complicating the sensing is the need to operate the device on the curved surface of the anterior chamber with minimum damage to the eye tissue. Therefore, a thin and flexible substrate is required. We fabricate sensors by exploiting Parylene as a biocompatible structural material in a suitable form factor and 25 μm thick liquid crystal polymer (LCP) as a soft and flexible host substrate. Using our approach, the flexibility and small form factor necessary for a mouse eye implant is achieved, along with the sensitivity required to monitor IOP fluctuations. This device will allow better study of glaucoma through close monitoring in mice after integration with other components.
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Acknowledgement
This work is funded by a Collaborative Innovation Award from the Howard Hughes Medical Institute (HHMI). The authors also wish to acknowledge the technical assistance of Special Coating System (SCS). SWMJ is an Investigator of the HHMI.
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Ha, D., de Vries, W.N., John, S.W.M. et al. Polymer-based miniature flexible capacitive pressure sensor for intraocular pressure (IOP) monitoring inside a mouse eye. Biomed Microdevices 14, 207–215 (2012). https://doi.org/10.1007/s10544-011-9598-3
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DOI: https://doi.org/10.1007/s10544-011-9598-3