Abstract
Occupational exposure to hexavalent chromium [Cr(VI)] has been firmly associated with the development of several pathologies, notably lung cancer. According to the current paradigm, the evolution of normal cells to a neoplastic state is accompanied by extensive metabolic reprogramming, namely at the level of energy-transducing processes. Thus, a complete understanding of the molecular basis of Cr(VI)-induced lung cancer must encompass the elucidation of the impact of Cr(VI) on metabolism. Research in this area is still in its infancy. Nonetheless, Cr(VI)-induced metabolic phenotypes are beginning to emerge. Specifically, it is now well documented that Cr(VI) exposure inhibits respiration and negatively affects the cellular energy status. Furthermore, preliminary results suggest that it also upregulates glucose uptake and lactic acid fermentation. From a mechanistic point of view, there is evidence that Cr(VI) exposure can interfere with energy transducing pathways at different levels, namely gene expression, intracellular protein levels and/or protein function. Loss of thiol redox control likely plays a key role in these processes. The transcriptional networks that control energy transduction can likewise be affected. Data also suggest that Cr(VI) exposure might compromise energy transducing processes through changes in the intracellular pools of their substrates. This article reviews, for the first time, the information available on Cr(VI) impact on mammalian cell bioenergetics. It aims to provide a framework for the understanding of the role played by bioenergetics in Cr(VI)-induced carcinogenesis and is also intended as a guide for future research efforts in this area.
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Notes
EC = ([ATP] + ½[ADP])/[ATP] + [ADP] + [AMP]).
Abbreviations
- BDH:
-
β-Hydroxybutyrate dehydrogenase
- Cr(III):
-
Trivalent chromium
- Cr(IV):
-
Tetravalent chromium
- Cr(V):
-
Pentavalent chromium
- Cr(VI):
-
Hexavalent chromium
- DCFH:
-
Dichlorodihydrofluorescein
- DHR:
-
Dihydrorhodamine
- EC:
-
Energy charge
- ETC:
-
Electron transport chain
- FDG-PET:
-
18-Fluorodeoxyglucose positron emission tomography
- G6PDH:
-
Glucose-6-phosphate dehydrogenase
- GAPDH:
-
Glyceraldehyde-3-phosphate dehydrogenase
- GPx:
-
Glutathione peroxidase
- GSH:
-
Reduced glutathione
- GSR:
-
Glutathione reductase
- GST:
-
Glutathione S-transferase
- KGDH:
-
α-Ketoglutarate dehydrogenase
- LDH:
-
Lactate dehydrogenase NHBE Normal human bronchial epithelial
- MCAD:
-
Medium-chain acyl-CoA dehydrogenase
- MDH:
-
Malate dehydrogenase
- NADPH:
-
Nicotinamide adenine dinucleotide phosphate
- OCR:
-
Oxygen consumption rate
- OXPHOS:
-
Oxidative phosphorylation
- PDH:
-
Pyruvate dehydrogenase
- PDK2:
-
Pyruvate dehydrogenase kinase isoform 2
- 3-PGK:
-
3-Phosphoglycerate kinase
- PGM:
-
Phosphoglucomutase
- PK:
-
Pyruvate kinase
- PPP:
-
Pentose phosphate pathway
- Prx:
-
Peroxiredoxin
- ROS:
-
Reactive oxygen species
- SCO2:
-
Synthesis of cytochrome c oxidase 2
- SOD:
-
Superoxide dismutase
- TCA:
-
Tricarboxylic acid
- TPI:
-
Triosephosphate isomerase
- Trx:
-
Thioredoxin
- Trx1:
-
Cytosolic thioredoxin
- Trx2:
-
Mitochondrial thioredoxin
- TrxR:
-
Thioredoxin reductase
- TrxR1:
-
Cytosolic thioredoxin reductase
- TrxR2:
-
Mitochondrial thioredoxin reductase
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Acknowledgments
Investigations from the authors’ laboratories described here were supported by Centro de Investigação em Meio Ambiente, Genética e Oncobiologia (CIMAGO), Portugal (Grants 26/07, to AMU, and 16/06, to MCA) and by Fundação para a Ciência e a Tecnologia, Portugal (Grant PEst-OE/QUI/UI0070/2011, to Unidade de Química Física Molecular). The authors apologize to all colleagues whose relevant work could not be mentioned and/or cited owing to space limitations.
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Abreu, P.L., Ferreira, L.M.R., Alpoim, M.C. et al. Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer. Biometals 27, 409–443 (2014). https://doi.org/10.1007/s10534-014-9726-7
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DOI: https://doi.org/10.1007/s10534-014-9726-7