Abstract
Objectives
Recent studies have revealed that circular RNA (circRNA) plays a pivotal role in cancer development. The study aimed to investigate the role of circ_0081146 in gastric cancer (GC).
Results
Circ_0081146 was upregulated in GC tissues and cells. Patients with high expression of circ_0081146 had a significantly reduced 5-year overall survival rate. Circ_0081146 knockdown restrained the growth, migration and invasion of GC cells in vitro as well as tumorigenesis in vivo. Circ_0081146 targeted miR-144 and HMGB1 was targeted by miR-144. Circ_0081146 was negatively correlated with miR-144 expression, while positively correlated with HMGB1 expression in GC tissues. Moreover, the inhibitory effect of circ_0081146 knockdown on the progression of GC cells were reversed by silencing miR-144 or HMGB1 overexpression. Mechanically, circ_0081146 increased HMGB1 expression by targeting miR-144.
Conclusion
Circ_0081146 functions as an oncogene in GC to promote cell growth, migration and invasion via modulating the miR-144/HMGB1 axis.
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Funding
This study was supported by Shanghai Pudong Commission of Health and Family Planning (No. PWRd2016-12); and Talents Training Program of Seventh People’s Hospital of Shanghai University of TCM (No. XX2019-07).
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Xu, Q., Liao, B., Hu, S. et al. Circular RNA 0081146 facilitates the progression of gastric cancer by sponging miR-144 and up-regulating HMGB1. Biotechnol Lett 43, 767–779 (2021). https://doi.org/10.1007/s10529-020-03058-x
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DOI: https://doi.org/10.1007/s10529-020-03058-x