Abstract
The role of c-FLIP in cell motility was investigated using RNA interference. Down-regulation of c-FLIP increased amounts of reactive oxygen species (ROS), while over-expression of c-FLIP produced opposite effect. ROS induced phosphorylation of Akt and impaired cell motility.
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Acknowledgements
This work was supported by grants from the Basic Research Program of the Korea Science & Engineering Foundation (0103026-1-2), Korea Research Foundation and Vascular System Research Center, Korea Research Foundation Grant (C00249) funded by the Korean Government (MOEHRD), and a grant from the Ministry of Health and Welfare of Korea (A050260).
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Shim, E., Lee, YS., Kim, H.Y. et al. Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells. Biotechnol Lett 29, 141–147 (2007). https://doi.org/10.1007/s10529-006-9213-5
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DOI: https://doi.org/10.1007/s10529-006-9213-5