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Comprehensive Analysis of UGT1A1 Genetic Polymorphisms in Chinese Tibetan and Han Populations

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Abstract

The study of polymorphism of the UGT1A1 gene has not been reported in the Chinese Tibetan population, and there are no comparisons of genetic polymorphism in the gene between Chinese Han and Tibetan populations. In this study, we directly sequenced the functional regions of the UGT1A1 gene in 200 unrelated healthy Chinese volunteers, detecting 20 variations (including five novel ones). The distributions of allele and genotype frequencies differ between the two groups. UGT1A1*6 is the major reduced functional variant in the populations, and the *27 allele was detected only in the Han group. Differences in the frequencies of the UGT1A1*6/*63 genotype between the Tibetan and Han populations were statistically significant (P = 0.009). Our genetic data might provide fundamental information for the advance of personalized medicine and will facilitate genotype-phenotype studies in larger populations.

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Acknowledgments

We are grateful to all the participants in this study. This work was supported by a grant from the National High Technology Research and Development Program of China (863 Program; No. 2009AA022710). We would like to express our sincere gratitude to Changfeng Li for his technical support for our study.

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Authors and Affiliations

  1. National Engineering Research Center for Miniaturized Detection System, College of Life Sciences, Northwest University, 386# Taibai North Road 229, Xi’an, 710069, Shaanxi, China

    Xiaoqing Zhang, Yuewen Wang, Wei Yan & Jin Yang

  2. 504 Section of Xi’an High-tech Institute, Xi’an, 710025, Shaanxi, China

    Xiaohong Meng

Authors
  1. Xiaoqing Zhang
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  2. Xiaohong Meng
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  3. Yuewen Wang
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  4. Wei Yan
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  5. Jin Yang
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Corresponding author

Correspondence to Jin Yang.

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Xiaoqing Zhang and Xiaohong Meng contributed equally to this work.

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Zhang, X., Meng, X., Wang, Y. et al. Comprehensive Analysis of UGT1A1 Genetic Polymorphisms in Chinese Tibetan and Han Populations. Biochem Genet 50, 967–977 (2012). https://doi.org/10.1007/s10528-012-9536-y

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  • DOI: https://doi.org/10.1007/s10528-012-9536-y

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