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Analysis of glucose metabolism in cynomolgus monkeys during aging

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Abstract

This study was designed to investigate the effect of aging on the glucose metabolism on cynomolgus (Macaca fascicularis) monkeys. A total of 33 cynomolgus monkeys in three aged groups were monitored for glucose levels, serum parameters in fasting state and somatometric measurements. Intravenous glucose tolerance test (IVGTT) and insulin tolerance test (ITT) were also performed. Aging associated changes lies in the less secretion of insulin and C-peptide during IVGTT in cynomolgus monkeys. It was also found that impaired insulin sensitivity occurred in female monkeys during aging based on HOMA-IR and KITT value. In addition, triglyceride level also rose with the increase of age. Less insulin secretion and impaired insulin sensitivity in female were the characteristic during the aging of cynomolgus monkeys in this study. Body mass index, weight and waist hip rate may be the relevant factors in insulin resistance of cynomolgus monkeys.

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Acknowledgments

We thank for DQ. Yi, DY. Yao, M. Yang, WY. Mo, WH. Qin for providing technical assistance. This work was supported in part by a grant from National Basic Research Program of China (Project Code: 2007CB947704), high level talent fund of the Beijing health care (2009-2-14), the scientific and technology development program sponsored by Guangxi Bureau of Scientific technology (201001010A), Program for supporting the developing country sponsored by Chinese Ministry of Scientific Technology 2010.

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Authors and Affiliations

  1. Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Science, and Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, People’s Republic of China

    Di Wu, Chunlin Zou & Y. Alex Zhang

  2. Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Science, and Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, People’s Republic of China

    Feng Yue & Piu Chan

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  1. Di Wu
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  2. Feng Yue
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  3. Chunlin Zou
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Correspondence to Y. Alex Zhang.

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Wu, D., Yue, F., Zou, C. et al. Analysis of glucose metabolism in cynomolgus monkeys during aging. Biogerontology 13, 147–155 (2012). https://doi.org/10.1007/s10522-011-9364-1

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