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IL-6 Gene Expression as a Marker of Pathological State in Psoriasis and Psoriatic Arthritis

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Bulletin of Experimental Biology and Medicine Aims and scope

The expression of the IL-6 gene in mononuclear blood cells of 45 patients with psoriatic arthritis and 31 patients with plaque psoriasis was studied for possible differential diagnosis of the pathologies. The expression level of IL-6 in psoriatic arthritis and psoriasis surpassed that in healthy controls by 192 and 147 times, respectively. Significant differences in the gene expression were revealed between the patients with psoriatic arthritis and mild psoriasis. The level of IL-6 in patients with severe psoriasis approached that in patients with psoriatic arthritis. High level of IL-6 gene expression can be a marker of possible joint damage in patients with psoriasis and a signal for revising the therapeutic approach in a particular patient.

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Authors and Affiliations

  1. Center for Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia

    V. V. Sobolev, E. V. Denisova & I. M. Korsunskaya

  2. Department of Children’s Diseases, N. F. Filatov Clinical Institute of Children’s Health, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    S. N. Chebysheva & N. A. Geppe

  3. Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia

    E. V. Denisova & I. M. Korsunskaya

Authors
  1. V. V. Sobolev
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  2. E. V. Denisova
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  3. S. N. Chebysheva
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  4. N. A. Geppe
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  5. I. M. Korsunskaya
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Correspondence to V. V. Sobolev.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 1, pp. 92-95, January, 2022

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Sobolev, V.V., Denisova, E.V., Chebysheva, S.N. et al. IL-6 Gene Expression as a Marker of Pathological State in Psoriasis and Psoriatic Arthritis. Bull Exp Biol Med 173, 77–80 (2022). https://doi.org/10.1007/s10517-022-05497-0

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  • DOI: https://doi.org/10.1007/s10517-022-05497-0

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