It was shown that finasteride, a 5α-reductase inhibitor (50 mg/kg, intraperitoneally) produced analgesic and antiexudative effects in experimental peritonitis induced by intraperitoneal injection of 1% acetic acid. These results agree with published data on its anti-inflammatory properties and ability to potentiate the analgesic effect of morphine in rodents. New pyrazolo[C] pyridine derivative GIZh-72 (4,6-dimethyl-2-(4-chlorphenyl)-2,3-dihydro-1H-pyrazolo[4,3-C]pyridine-3-on, chloral hydrate) injected intraperitoneally in doses of 20-80 mg/kg produced dose-dependent antiexudative effects, but exhibited no analgesic properties.
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Ivanova EA, Voronina TA. Effect of the main metabolite of afobazole M-11 on acute exudative inflammation and visceral pain in mice. Farmakokinetika Farmakodinamika. 2016;(2):46- 48. Russian.
Kudryashov NV, Kalinina TS, Kasabov KA, Shimshirt AA, Volkova AV, Zhmurenko LA, Kudrin VS, Voronina TA. The role of neurosteroids metabolism in anticompulsive effect of pyrazole[c]pyridine derivative GIZH-72. Eksp. Klin. Farmakol. 2018;81(2):7-11. Russian.
Kudryashov NV, Kalinina TS, Shimshirt AA, Korolev AO, Volkova AV, Zhmurenko LA, Voronina TA. The Study of Anxiolytic Properties of New Pyrazolo[c]pyridine Derivative GIZh-72. Eksp. Klin. Farmakol. 2015;78(11):3-7. Russian.
Aksoy AN, Toker A, Celık M, Aksoy M, Halıcı Z, Aksoy H. The effect of progesterone on systemic inflammation and oxidative stress in the rat model of sepsis. Indian J. Pharmacol. 2014;46(6):622-626.
De Nicola AF, Garay LI, Meyer M, Guennoun R, Sitruk-Ware R, Schumacher M, Gonzalez Deniselle MC. Neurosteroidogenesis and progesterone anti-inflammatory/neuroprotective effects. J. Neuroendocrinol. 2018;30(2. doi: 10.1111/jne.12502
Duborija-Kovacevic N, Jakovljevic V, Sabo A, Tomic Z. Antinociceptive and anti-inflammatory properties of 5alpha-reductase inhibitor finasteride in experimental animals. Eur. J. Drug Metab. Pharmacokinet. 2008;33(3):181-186.
Finn DA, Beadles-Bohling AS, Beckley EH, Ford MM, Gililland KR, Gorin-Meyer RE, Wiren KM. A new look at the 5alpha-reductase inhibitor finasteride. CNS Drug Rev. 2006; 12(1):53-76.
Gilliver SC, Ashworth JJ, Mills SJ, Hardman MJ, Ashcroft GS. Androgens modulate the inflammatory response during acute wound healing. J. Cell Sci. 2006;119(Pt 4):722-732.
Joel D, Stein DJ, Schreiber R. Animal Models of Obsessive- Compulsive Disorder. Animal and Translational Models for CNS Drug Discovery. Borsini F, ed. San Diego, 2008. P. 133- 164.
Lei B, Mace B, Dawson HN, Warner DS, Laskowitz DT, James ML. Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. PLoS One. 2014;9(7). ID e103969. doi: 10.1371/journal.pone.0103969
Sorbellini E, Pinto D, Marzani B, Rinaldi F. Drug treatment for androgenetic alopecia: first Italian questionnaire survey on what dermatologists think about finasteride. Dermatol. Ther (Heidelb). 2018;8(2):259-267.
Verdi J, Ahmadiani A. Finasteride, a 5alpha-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat. Horm. Behav. 2007;51(5):605-610.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 10, pp. 435-438, October, 2019
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Kudryashov, N.V., Ivanova, E.A., Kalinina, T.S. et al. Antiexudative Effects of Finasteride and a New Pyrazolo[C]Pyridine Derivative GIZh-72 in Acetic Acid-Induced Experimental Peritonitis. Bull Exp Biol Med 168, 453–456 (2020). https://doi.org/10.1007/s10517-020-04730-y
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DOI: https://doi.org/10.1007/s10517-020-04730-y