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Analysis of Antitumor Activity of the Liposomal Photosensitizer Lipophthalocyan

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied specific antitumor activity of a liposomal drug based on tetra-3-phenylthiophthalocyanine aluminum hydroxide (lipophthalocyan) intended for photodynamic therapy. The optimal dose and protocol for photodynamic therapy with lipophthalocyan were chosen in experiments on mice: single intravenous dose of 6 mg/kg with a 5-h interval between administration and laser exposure and irradiation energy density of 400 J/cm2. A wide spectrum antitumor activity of lipophthalocyan was demonstrated in vivo for various transplantable mouse tumors (Lewis lung epidermoid carcinoma, S37 sarcoma, and colon adenocarcinoma AKATOL). The results show the possibility of using lipophthalocyan for photodynamic therapy of tumors of surface localization (skin and mucosa tumors).

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Authors and Affiliations

  1. N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia

    A. V. Lantsova, L. M. Borisova, M. P. Kiseleva, E. V. Sanarova, O. L. Orlova, M. V. Dmitrieva, A. P. Polozkova, N. A. Oborotova & L. L. Nikolaeva

  2. A. M. Prokhorov Institute of General Physics, Russian Academy of Sciences, Moscow, Russia

    G. A. Meerovich

  3. I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    N. D. Bunyatyan, Yu. V. Olefir, A. B. Prokof’ev, M. M. Sapovskii & L. L. Nikolaeva

  4. Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Health of Russia, Moscow, Russia

    N. D. Bunyatyan, Yu. V. Olefir, A. B. Prokof’ev & V. A. Evteev

  5. Pyatigorsk Medical and Pharmaceutical Institute, Branch of the Volgograd State Medical University, Ministry of Health of the Russian Federation, Pyatigorsk, Russia

    M. A. Ogay & Z. J. Khadzhieva

Authors
  1. A. V. Lantsova
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  2. L. M. Borisova
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  3. G. A. Meerovich
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  4. N. D. Bunyatyan
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  5. Yu. V. Olefir
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  6. A. B. Prokof’ev
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  7. V. A. Evteev
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  8. M. M. Sapovskii
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  9. M. P. Kiseleva
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  10. E. V. Sanarova
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  11. O. L. Orlova
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  12. M. V. Dmitrieva
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  13. A. P. Polozkova
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  14. N. A. Oborotova
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  15. M. A. Ogay
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  16. Z. J. Khadzhieva
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  17. L. L. Nikolaeva
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Corresponding author

Correspondence to N. D. Bunyatyan.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 9, pp. 332-337, September, 2019

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Lantsova, A.V., Borisova, L.M., Meerovich, G.A. et al. Analysis of Antitumor Activity of the Liposomal Photosensitizer Lipophthalocyan. Bull Exp Biol Med 168, 361–365 (2020). https://doi.org/10.1007/s10517-020-04709-9

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  • DOI: https://doi.org/10.1007/s10517-020-04709-9

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