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Effect of Phytoadaptogen Administration during Early Ontogeny on Lifespan and Somatic Status of CBA Mice with High Incidence of Tumors

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We studied the influence of nontoxic phytoadaptogen complex on the lifespan and somatic status (body weight, coat state, and motor activity) of CBA mice predisposed to spontaneous hepatomas. Administration of the complex phytoadaptogen during the first month of postnatal ontogeny increased mean animal lifespan by 17.1% (p<0.001) and median of survival by 25.6% (p<0.001) and promoted maintenance of satisfactory physical status of CBA mice during spontaneous hepatocarcinogenesis.

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Authors and Affiliations

  1. N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

    E. V. Bocharov, R. V. Karpova, O. A. Bocharova & Z. S. Shprakh

  2. Research Institute of General Pathology and Pathophysiology, Moscow, Russia

    V. G. Kucheryanu

Authors
  1. E. V. Bocharov
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  2. R. V. Karpova
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  3. O. A. Bocharova
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  4. V. G. Kucheryanu
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  5. Z. S. Shprakh
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Corresponding author

Correspondence to R. V. Karpova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 6, pp. 755-758, June, 2017

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Bocharov, E.V., Karpova, R.V., Bocharova, O.A. et al. Effect of Phytoadaptogen Administration during Early Ontogeny on Lifespan and Somatic Status of CBA Mice with High Incidence of Tumors. Bull Exp Biol Med 163, 789–792 (2017). https://doi.org/10.1007/s10517-017-3904-x

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  • DOI: https://doi.org/10.1007/s10517-017-3904-x

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