Skip to main content

Advertisement

Log in

Antiproliferative Effects of Modified Bioflavonoid in Ex Vivo Model

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of modified bioflavonoid and reference drug quercetin dihydrate on proliferation of mononuclears triggered by T- and B-cell mitogens. Lymphocytes were in vivo pretreated with the examined agents followed by their explantation and in vitro activation with T- and B-cell mitogens in cell culture. Intraperitoneal injection of modified bioflavonoid and quercetin dihydrate produced a dose-dependent inhibition of proliferation of the in vitroactivated splenocytes; modified bioflavonoid demonstrated higher antiproliferative activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Atluru D, Jackson TM, Atluru S. Genistein, a selective protein tyrosine kinase inhibitor, inhibits interleukin-2 and leukotriene B4 production from human mononuclear cells. Clin. Immunol. Immunopathol. 1991; 59(3):379-387.

    Article  CAS  PubMed  Google Scholar 

  2. Chauhan PS, Satti NK, Suri KA, Amina M, Bani S. Stimulatory effects of Cuminum cyminum and flavonoid glycoside on Cyclosporine-A and restraint stress induced immune-suppression in Swiss albino mice. Chem. Biol. Interact. 2010; 185(1):66-72.

    Article  CAS  PubMed  Google Scholar 

  3. Chen CC, Chow MP, Huang WC, Lin YC, Chang YJ. Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. Mol. Pharmacol. 2004; 66(3):683-693.

    CAS  PubMed  Google Scholar 

  4. Chen M, Gu H, Ye Y, Lin B, Sun L, Deng W, Zhang J, Liu J. Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes. Food Chem. Toxicol. 2010; 48(10):2980-2987.

    Article  CAS  PubMed  Google Scholar 

  5. Chen SR, Xu XZ, Wang YH, Chen JW, Xu SW, Gu LQ, Liu PQ. Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways. Biol. Pharm. Bull. 2010; 33(8):1307-1313.

    Article  CAS  PubMed  Google Scholar 

  6. Dagne A, Melkamu T, Schutten MM, Qian X, Upadhyaya P, Luo X, Kassie F. Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice. Carcinogenesis. 2011; 32(4):561-567.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Donfack JH, Simo CC, Ngameni B, Tchana AN, Kerr PG, Finzi PV, Vidari G, Giardina S, Buonocore D, Ngadjui BT, Moundipa PF, Marzatico F. Antihepatotoxic and antioxidant activities of methanol extract and isolated compounds from Ficus chlamydocarpa. Nat. Prod. Commun. 2010; 5(10):1607-1612.

    CAS  PubMed  Google Scholar 

  8. Feng YH, Zhou WL, Wu QL, Li XY, Zhao WM, Zou JP. Low dose of resveratrol enhanced immune response of mice. Acta. Pharmacol. Sin. 2002; 23(10):893-897.

    CAS  PubMed  Google Scholar 

  9. Funakoshi-Tago M, Tago K, Nishizawa C, Takahashi K, Mashino T, Iwata S, Inoue H, Sonoda Y, Kasahara T. Licochalcone A is a potent inhibitir of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation. Biochem. Pharmacol. 2008; 76(12):1681-1693.

    Article  CAS  PubMed  Google Scholar 

  10. Guruvayoorappan C, Kuttan G. Amentoflavone, a biflavonoid from Biophytum sensitivum augments lymphocyte proliferation, natural killer cell and antibody dependent cellular cytotoxicity through enhanced production of IL-2 and IFN-gamma

  11. and restrains serum sialic acid and gamma glutamyl transpeptidase production in tumor--bearing animals. J. Exp. Ther. Oncol. 2007; 6(4):285-295.

  12. Lee JY, Lee JH, Park JH, Kim SY, Choi JY, Lee SH, Kim YS, Kang SS, Jang EC, Han Y. Liquiritigenin, a licorice flavonoid, helps mice resist disseminated candidiasis due to Candida albicans by Th1 immune response, whereas liquiritin, its glycoside form, does not. Int. Immunopharmacol. 2009; 9(5):632-638.

    Article  CAS  PubMed  Google Scholar 

  13. Lu J, Wang JS, Kong LY. Anti-inflammatory effects of Huang-Lian-Jie-Du decoction, its two fractions and four typical compounds. J. Ethnopharmacol. 2011; 134(3):911-918.

    Article  CAS  PubMed  Google Scholar 

  14. Nishizuka T, Fujita Y, Sato Y, Nakano A, Kakino A, Ohshima S, Kanda T, Yoshimoto R, Sawamura T. Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox. Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. 2011; 87(3):104-113.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zh. K. Albegova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 3, pp. 359-361, March, 2016

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Albegova, D.Z., Kamkina, O.V., Pavlova, S.I. et al. Antiproliferative Effects of Modified Bioflavonoid in Ex Vivo Model. Bull Exp Biol Med 161, 381–383 (2016). https://doi.org/10.1007/s10517-016-3419-x

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-016-3419-x

Key Words

Navigation