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Insulin-Like Growth Factors (IGF) and IGF-Binding Proteins (IGFBP) in the Serum of Patients with Ovarian Tumors

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Bulletin of Experimental Biology and Medicine Aims and scope

IGF-1, IGF-2, and IGFBP-1,2,3 were assayed in blood serum of patients with malignant ovarian tumors (n=44), borderline ovarian tumors (n=11), and benign ovarian tumors (n=12) as well as in healthy women (n=33). In blood serum of patients with malignant ovarian tumors, the level of IGF-1 was lower and IGFBP-1 was higher than in other groups. In patients with malignant and borderline ovarian tumors, the level of IGFBP-2 was higher than in healthy women and in patients with benign ovarian tumors. There was no correlation between most examined parameters and the clinical and morphological peculiarities of ovarian tumors. The study revealed IGF/IGFBP imbalance in patients with malignant ovarian tumor and showed that IGFBP-2 proved to be a potential diagnostic serological marker w with 90% sensitivity and 90% specificity.

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Authors and Affiliations

  1. N. N. Blokhin Russian Cancer Research Center, Moscow, Russia

    E. R. Isaeva, E. A. Korotkova, V. D. Ermilova & K. P. Laktionov

  2. V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

    E. S. Gershtein, D. N. Kushlinsky & L. V. Adamyan

Authors
  1. E. S. Gershtein
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  2. E. R. Isaeva
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  3. D. N. Kushlinsky
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  4. E. A. Korotkova
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  5. V. D. Ermilova
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  6. K. P. Laktionov
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  7. L. V. Adamyan
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Corresponding author

Correspondence to E. S. Gershtein.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 12, pp. 787-790, December, 2015

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Gershtein, E.S., Isaeva, E.R., Kushlinsky, D.N. et al. Insulin-Like Growth Factors (IGF) and IGF-Binding Proteins (IGFBP) in the Serum of Patients with Ovarian Tumors. Bull Exp Biol Med 160, 814–816 (2016). https://doi.org/10.1007/s10517-016-3317-2

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  • DOI: https://doi.org/10.1007/s10517-016-3317-2

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