We analyzed the effect of hemolysis on microRNA profi le of blood plasma. It was found that hemolysis of ~0.05% erythrocytes in a sample signifi cantly affected the concentration of 9 microRNA: hsa-miR-486-5p, hsa-miR-16-5p, hsa-miR-451a, hsa-miR-106a-5p, hsa-miR-17-5p, hsa-miR-93-5p, hsa-miR-20a-5p, hsa-miR-107, and hsa-miR-20b-5p. The effect of hemolysis on plasma content of miR-17 family microRNA was demonstrated.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 12, pp. 709–711, December, 2015
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Shkurnikov, M.Y., Knyazev, E.N., Fomicheva, K.A. et al. Analysis of Plasma microRNA Associated with Hemolysis. Bull Exp Biol Med 160, 748–750 (2016). https://doi.org/10.1007/s10517-016-3300-y
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DOI: https://doi.org/10.1007/s10517-016-3300-y