Magnetic resonance tomography was employed to verify endothelial dysfunction of renal arteries in Wistar and OXYS rats under conditions of induced arterial hypertension. Angiography revealed changes in the size and form of renal arteries of hypertensive animals. In hypertensive rats, histochrome exerted a benevolent therapeutic effect in renal arteries: it decreased BP, diminished thrombus formation in fi ne capillaries and arterioles, demonstrated the anticoagulant properties, partially improved endothelial dysfunction of small renal arteries, and up-regulated the glomerular filtration.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
I. G. Agafonova, N. G. Kolosova, N. P. Mishchenko, et al., Bull. Exp. Biol. Med., 143, No. 4, 467–471 (2007).
I. G. Agafonova, V. N. Kotel’nikov, N. P. Mishchenko, and N. G. Kolosova, Bull. Exp. Biol. Med., 150, No. 6, 739–743 (2011).
V. M. Bryukhanov, Ya. F. Zverev, V. V. Lampatov, and A. Yu. Zharikov, Nefrologiya, 13, No. 3, 52–62 (2009).
N. P. Mishchenko, S. A. Fedoreev, and V. L. Bagirova, Khim. Farmakol. Zh., 37, No. 1, 49–53 (2003).
N. V. Motina, V. M. Bryukhanov, Ya. F. Zverev, et al., Nefrologiya, 15, No. 2, 57–61 (2011).
Yu. G. Motin, A. Yu. Zharikov, V. M. Bryukhanov, et al., Morfo logiya, 5, No. 1, 33–37 (2011).
T. P. Novgorodtseva and E. A. Endakova, Methods for Testing “LPO–Antioxidant Protection” Parameters in Biological Fluids [in Russian], Moscow (2003).
T. P. Novgorodtseva, M. V. Antonyuk, V. N. Kotel’nikov, et al., Patent RF No. 2327228. A Method to Model the Cardiovasorenal Arterial Hypertension in Rats, Byull. Izobr., No. 17, June 20, 2008.
O. S. Talalaeva, A. Yu. Zharikov, Ya. F. Zverev, et al., Byull. Sib. Med., 12, No. 3, 69–75 (2013).
O. S. Talalaeva and N. P. Mishchenko, Byull. Sib. Med., 10, No. 5, 101–105 (2011).
A. N. Shishkin and M. L. Lyndina, Arter. Gipertenz., 14, No. 4, 315–319 (2008).
T. A. Shteklina and N. G. Kolosova, Ross. Fiziol. Zh., 91, No. 10, 1213–1220 (2005).
I. G. Agafonova, V. N. Kotel’nikov, and U. Eichoff, Appl. Magn. Reson., 45, No. 6, 527–536 (2014).
R. D. Manning Jr, N. Tian, and S. Meng, Am. J. Nephrol., 25, No. 4, 311–317 (2005).
R. Rodrigo, J. Gonzalez, and F. Paoletto, Hypertens. Res., 34, No. 4, 431–440 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 8, pp. 187–191, August, 2015
Rights and permissions
About this article
Cite this article
Agafonova, I.G., Bogdanovich, R.N. & Kolosova, N.G. Assessment of Nephroprotective Potential of Histochrome during Induced Arterial Hypertension. Bull Exp Biol Med 160, 223–227 (2015). https://doi.org/10.1007/s10517-015-3134-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-015-3134-z