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Identifi cation of Central Nervous System Proteins in Human Blood Serum and Plasma

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Bulletin of Experimental Biology and Medicine Aims and scope

Mass-spectrometric identification of proteins in human blood plasma and serum was performed by comparing mass-spectra of fragmented peptides using Swiss-Prot and UniProtKB databases of amino acid sequences. After choosing the appropriate identification conditions we found that combination of spectrum search parameters are optimal for identification of CNS proteins. In the studied plasma and serum samples, 9 proteins involved into pathological processes in the nervous tissue were identified; 7 of them were identified in both plasma and serum.

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Authors and Affiliations

  1. V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

    Yu. V. Miroshnichenko, N. A. Petushkova, A. V. Lisitsa, V. G. Zgoda & A. Yu. Belyaev

  2. N. N. Burdenko Research Institute of Neurosurgery, Russian Academy of Medical Sciences, Moscow, Russia

    N. B. Teryaeva & A. A. Potapov

Authors
  1. Yu. V. Miroshnichenko
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  2. N. A. Petushkova
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  3. N. B. Teryaeva
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  4. A. V. Lisitsa
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  5. V. G. Zgoda
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  6. A. Yu. Belyaev
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  7. A. A. Potapov
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Corresponding author

Correspondence to Yu. V. Miroshnichenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 7, pp. 41-46, July, 2015

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Miroshnichenko, Y.V., Petushkova, N.A., Teryaeva, N.B. et al. Identifi cation of Central Nervous System Proteins in Human Blood Serum and Plasma. Bull Exp Biol Med 160, 35–39 (2015). https://doi.org/10.1007/s10517-015-3092-5

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  • DOI: https://doi.org/10.1007/s10517-015-3092-5

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