Compound RU-792 showed pronounced anti-ischemic activity and improved survival of rats with brain ischemia by normalizing parameters of spontaneous motor activity and reducing neurological deficit within 3 post-operative days being superior to the reference drug mexidol by this parameter. RU-792 inhibited the formation of conjugated dienes and malonic dialdehyde and increased activity of the antioxidant enzyme glutathione peroxidase thereby modulating the parameters of free radical oxidation in rats subjected to ischemia more effectively than mexidol.
Similar content being viewed by others
References
L. I. Andreeva, L. A. Kozhemyakin, and A. A. Kishkun, Lab. Delo, No. 11, 41-43 (1988).
Ya . Buresh, O. Bureshova, and J.P. Houston, Techniques and Basic Experiments for Studying Brain and Behavior [in Russian], Moscow (1991).
V. B. Gavrilov, A. R. Gavrilova, and L. M. Mazhul’, Vopr. Med. Khimii, 33, No. 1, 118-122 (1987).
V. S. Kamyshnikov, Clinical and Biochemical Laboratory Diag nostics [in Russian], Minsk (2003).
V. A. Kosolapov, L. V. Eltsova, A. A. Spasov, and V. A. Anisimova, Bull. Exp. Biol. Med., 155, No. 4, 461-463(2013).
M. A. Lutskii, R. V. Tonkikh, and A. P. Anibal, Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova, Suppl. “Insult”, Issue 2, No. 5, 73-80 (2009).
R. S. Mirzoyan, M. B. Plotnikov, T. S. Gan’shina, et al., Guidelines for Pre-Clinical Trials of Medicinal Products [in Russian], Pt I, Moscow (2012), pp. 478-485.
E. M. Moin, Lab. Delo, No. 12, 724-727 (1986).
V. N. Perfi lova, I. N. Tyurenkov, O. Yu. Grechko, and Yu. V. Lamtyugin, Vestn. Volgograd. Gos. Med. Univer, No. 1, pp. 74-76 (2010).
I. N. Tyurenkov, M. N. Bagmetov, and V. V. Yepishina, Eksp. Klin. Farmakol., 70, No. 2, 24-29 (2007).
K. Gohil and A. A. Chakraborty, Nutrition, 20, No. 1, 50-55 (2004).
L. X. Li, K. Campbell, S. Zhao, et al., Brain Res. Bull., 86, Nos. 5-6, 390-394 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 353-356, March, 2015
Rights and permissions
About this article
Cite this article
Kosolapov, V.A., Sorotskii, D.V., Spasov, A.A. et al. Effect of Pyrrolobenzimidazole Derivative RU-792 on Experimental Brain Ischemia. Bull Exp Biol Med 159, 372–375 (2015). https://doi.org/10.1007/s10517-015-2966-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-015-2966-x