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Effect of Pyrrolobenzimidazole Derivative RU-792 on Experimental Brain Ischemia

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Compound RU-792 showed pronounced anti-ischemic activity and improved survival of rats with brain ischemia by normalizing parameters of spontaneous motor activity and reducing neurological deficit within 3 post-operative days being superior to the reference drug mexidol by this parameter. RU-792 inhibited the formation of conjugated dienes and malonic dialdehyde and increased activity of the antioxidant enzyme glutathione peroxidase thereby modulating the parameters of free radical oxidation in rats subjected to ischemia more effectively than mexidol.

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Authors and Affiliations

  1. Department of Pharmacology, Rostov-on-Don, Russia

    V. A. Kosolapov & A. A. Spasov

  2. Laboratory of Pharmacology of Antioxidant Substances, Research Institute of Pharmacology, Volgograd State Medical Academy, Rostov-on-Don, Russia

    V. A. Kosolapov & D. V. Sorotskii

  3. Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia

    V. A. Anisimova

Authors
  1. V. A. Kosolapov
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  2. D. V. Sorotskii
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  3. A. A. Spasov
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  4. V. A. Anisimova
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Corresponding author

Correspondence to V. A. Kosolapov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 353-356, March, 2015

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Kosolapov, V.A., Sorotskii, D.V., Spasov, A.A. et al. Effect of Pyrrolobenzimidazole Derivative RU-792 on Experimental Brain Ischemia. Bull Exp Biol Med 159, 372–375 (2015). https://doi.org/10.1007/s10517-015-2966-x

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  • DOI: https://doi.org/10.1007/s10517-015-2966-x

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