We studied in vitro and in vivo neuroprotective and antioxidant properties of neuroglutam, a new glutamic acid derivative. In experiments on immortalized mouse hippocampal cell line HT22, neuroglutam exhibited a neuroprotective effect in the model of oxidative stress after its introduction, both before and after H2O2. In vivo study on animals treated with neuroglutam against the background of cerebral ischemia modeled by irreversible occlusion of the common carotid arteries showed that plasma level of TBA-active products was signifi cantly lower and activities of cell antioxidant enzymes (superoxide dismutase and catalase) were higher than in control animals receiving saline under the same conditions.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
S. G. Burchinskii, Zdorov’ye Ukrainy, No. 19, 70-71 (2008).
S. G. Burchinskii, Mezhdunarodnyi Nevrologicheskii Zh., No. 1 [URL: www.mif-ua.com/archive/article-print/8106] (2009).
E. V. Volotova, D. V. Kurkin, I. N. Tyurenkov, and A. A. Lit vinov, Vestn. Volgograd. Gos. Med. Univer., No. 2, 72-75 (2011).
E. V. Volotova, N. V. Mazina, D. V. Kurkin, and I. N. Tyurenkov, Vestn. Volgograd. Gos. Med. Univer., No. 1, 40-42 (2013).
M. A. Korolyuk, L. I. Ivanova, N. O. Maiorova, et al., Lab. Delo, No. 1, 16-19 (1988).
V. A. Kostyuk, A. I. Potapovich, and Zh. V. Kovaleva, Vopr. Med. Khimii, 36, No. 2, 88-91 (1990).
T. V. Sologub, M. G. Romantsov, I. V. Kremen’, et al., Free Radical Processes and Infl ammation (Pathogenic, Clinical and Therapeutic Aspects) [in Russian], Moscow (2008).
V. I. Petrov, I. N. Tyurenkov, V. V. Bagmetova, et al., Patent RF No. 2429834. Agent Exhibiting Antidepressant, Anxiolytic, Neuroprotective and Immunostimulatory Effects, Byull., No. 27, September 27, 2011.
I. A. Tregubova, V. A. Kosolapov, and A. A. Spasov, Uspekhi Fiziol. Nauk, 43, No. 1, 75-94 (2012).
A. I. Fedin, Atmosfera: Nervnye Bolezni, No. 1, 15-18 (2002).
G. R. Jackson, K. Werrbach-Perez, E. L. Ezell, et al., Brain Res., 592, No. 1-2, 239-248 (1992).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 344-347, March, 2015
Rights and permissions
About this article
Cite this article
Tyurenkov, I.N., Volotova, E.V., Kurkin, D.V. et al. Neuroprotective and Antioxidant Effects of Neuroglutam in Cerebral Ischemia. Bull Exp Biol Med 159, 365–367 (2015). https://doi.org/10.1007/s10517-015-2964-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-015-2964-z