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Antihypoxic Activity of Cycloprolylglycine Analogs

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied antihypoxic activity of analogs of endogenous cyclic dipeptide cycloprolylglycine in a mouse model of normobaric hypoxia with hypercapnia and found that antixypoxic effect depends on the structure of the substance. It was shown that different pharmacophores are responsible for the antihypoxic, nootropic, and anxiolytic effects of cycloprolylglycine.

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References

  1. T. A. Voronina, R. U. Ostrovskaya, Manual of Experimental (Preclinical) Studies of New Drugs. Ed. R. U. Khabriev [in Russian], Moscow (2005), pp. 308-320.

  2. T. A. Gudasheva, I. I. Vasilevich, N. N. Zolotov, et al., Khim.-Farm. Zh., 25, No. 6, 12-16 (1991).

    CAS  Google Scholar 

  3. T. A. Gudasheva, M. A. Konstantinopol’skii, R. U. Ostrovskaya, and S. B. Seredenin, Bull. Exp. Biol. Med., 131, No. 5, 464-466 (2001).

    Article  CAS  PubMed  Google Scholar 

  4. T. A. Gudasheva, R. U. Ostrovskaya, S. S. Trofimov, et al., Khim.-Farm. Zh., 19, No. 11, 1322-1324 (1985).

    CAS  Google Scholar 

  5. T. A. Gudasheva, R. U. Ostrovskaya, S. S. Trofimov, et al., Bull. Exp. Biol. Med., 128, No. 10, 1012-1014 (1999).

    Article  CAS  Google Scholar 

  6. K. N. Kolyasnikova, M. V. Vichuzhanin, M. A. Konstantinopol’skii, et al., Khim.-Farm. Zh., 46, No. 2, 31-37 (2012).

    Google Scholar 

  7. K. N. Kolyasnikova, T. A. Gudasheva, G. A. Nazarova, et al., Eksp. Klin. Farmakol., 75, No. 9, 3-6 (2012).

    CAS  Google Scholar 

  8. S. B. Seredenin, T. A. Gudasheva, S. S. Boiko, et al., Bull. Exp. Biol. Med., 133, No. 4, 360-362 (2002).

    Article  CAS  PubMed  Google Scholar 

  9. T. A. Gudasheva, S. S. Boyko, V. Kh. Akparov, et al., FEBS Lett., 391, Nos. 1-2, 149-152 (1996).

    Article  CAS  PubMed  Google Scholar 

  10. L. H. Tran, Neuroprotection and Neuroegenisis by Administe ring Cyclic Prolyl Glycine, Patent US N 7232798, June 19, 2007.

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Authors and Affiliations

  1. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    K. N. Kolyasnikova, G. A. Nazarova, T. A. Gudasheva, T. A. Voronina & S. B. Seredenin

Authors
  1. K. N. Kolyasnikova
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  2. G. A. Nazarova
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  3. T. A. Gudasheva
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  4. T. A. Voronina
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  5. S. B. Seredenin
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Corresponding author

Correspondence to K. N. Kolyasnikova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 10, pp. 457-460, October, 2014

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Kolyasnikova, K.N., Nazarova, G.A., Gudasheva, T.A. et al. Antihypoxic Activity of Cycloprolylglycine Analogs. Bull Exp Biol Med 158, 458–460 (2015). https://doi.org/10.1007/s10517-015-2784-1

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  • DOI: https://doi.org/10.1007/s10517-015-2784-1

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