Skip to main content
SpringerLink
Log in

Peptides Stimulate Expression of Signal Molecules in Neuronal Cultures from Animals of Different Age

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Molecular mechanisms of the neuroprotective effect of peptide T-33 and cortexin were studied on organotypic cultures of the brain from young and old Wistar rats. The effective concentration of peptide T-33 stimulating proliferative activity of neurons considerably surpassed that of cortexin. Cortexin and peptide T-33 stimulated the expression of serotonin, Ki-67, and vimentin in cells of the brain cortex; peptide T-33 was most effective in this respect.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D. C. Granstem, E. G. Sorokina, T. P. Storozhevykh, et al., Terra Medica Nova, No. 5, 1-4 (2008).

  2. I. V. Zarubina and P. D. Shabanov, Eksp. Klin. Farmakol., 74, No. 2, 8-15 (2011).

    PubMed  CAS  Google Scholar 

  3. V. G. Morozov, G. A. Ryzhak, V. V. Malinin, and V. N. Rutkovskaya, [in Russian], St. Petersburg (2011). не переведено название книги!

  4. V. G. Morozov, V. H. Khavinson, O. V. Chayia, and V. I. Semenova, Patent RF No. 2104702. A Method for Preparation of Biologically Active Polypeptides of Animal Origin Normalizing Brain Function. Pharmacological Composition and its Application, Bull. Izobr., No. 20, June 27, 2009.

  5. V. H. Khavinson, E. I. Grigor’ev, V. V. Malinin, and G. A. Ryzhak, Patent RF No. 2301678. A Peptide Stimulating Regeneration of Neurons of the Central Nervous System, Pharmaceutical Compositions on This Basis and Method of Application, Bull. Izobr., No. 18, June 27, 2007.

  6. Yu. P. Petrov and N. V. Tsupkina, Tsitologiya, 54, No. 10, 754-760 (2012).

    Google Scholar 

  7. M. M. Tanashyan, D. Yu. Barkhatov, N. A. Glotova, et al., Vestn. Ross. Voen.-Med. Akad., 3, No. 35, 181-187 (2011).

    Google Scholar 

  8. V. N. Anisimov and V. Kh. Khavinson, Biogerontology, 11, No. 2, 139-149 (2010).

    Article  PubMed  CAS  Google Scholar 

  9. A. Arutjunyan, L. Kozina, S. Stvolinskiy, et al., Int. J. Clin. Exp. Med.., 5, No. 2, 179-185 (2012).

    PubMed  PubMed Central  Google Scholar 

  10. L. I. Fedoreyeva, T. A. Smirnova, G. Y. Kolomijtseva, et al., Biochemistry (Mosc.), 78, No. 2, 166-175 (2013).

    Article  CAS  Google Scholar 

  11. V. Kh. Khavinson, V. G. Morozov, V. V. Malinin, and E. I. Grigoriev, USA Patent 7189701. Tetrapeptide Stimulating Functional Activity of Neurons. Pharmacological Agent Based thereon and Method of Use thereof. March, 2007.

  12. V. Khavinson, Y. Ribakova, K. Kulebiakin, et al., Rejuvenation Res., 14, No. 5, 535-541 (2011).

    Article  PubMed  CAS  Google Scholar 

  13. V. Kh. Khavinson, N. S. Linkova, V. E. Pronyaeva, et al., Bull. Exp. Biol. Med., 153, No. 5, 795-799 (2012).

    Article  PubMed  CAS  Google Scholar 

  14. E. Scarpa, A. Roycroft, E. Theveneau, et al., Biol. Open., 12, No. 9, 901-906 (2013).

    Article  Google Scholar 

  15. A. Shpakov, O. Chistyakova, K. Derkach, and V. Bondareva, Neurodegenerative Diseases – Processes, Prevention, Protection and Monitoring. Rijeka (2011), pp. 349-386.

Download references

Author information

Authors and Affiliations

  1. St. Petersburg Institute of Bioregulation and Gerontology, Russian Academy of Sciences, St. Petersburg, Russia

    R. S. Umnov, N. S. Lin’kova & V. Kh. Khavinson

  2. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    V. Kh. Khavinson

Authors
  1. R. S. Umnov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. S. Lin’kova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. Kh. Khavinson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. S. Lin’kova.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 123-126, June, 2014

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Umnov, R.S., Lin’kova, N.S. & Khavinson, V.K. Peptides Stimulate Expression of Signal Molecules in Neuronal Cultures from Animals of Different Age. Bull Exp Biol Med 157, 701–704 (2014). https://doi.org/10.1007/s10517-014-2646-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-014-2646-2

Key Words

Search

Navigation