We studied isolated and combined effects of leptin and ghrelin on the formation of ILproducing and T-regulatory cells. Leptin in concentrations comparable with its normal blood concentration during pregnancy (trimester II-III) promotes differentiation of peripheral blood CD4+ cells to IL-17-producing cells and enhances IL-17A production, but suppresses the formation of T-regulatory cells in vitro. In contrast, ghrelin in a concentration typical of trimester I-II of pregnancy reduces the number of IL-17-producing cells, but stimulated the formation of T-regulatory cells. The effects of leptin and ghrelin in combination typical of trimester I-II of pregnancy stimulated the formation of T-regulatory cells, while in combination typical of trimester II-III did not shift the balance of T-regulatory cells and IL-17-producing cells, but stimulated the formation of IL-17A. We conclude that leptin and ghrelin play an important role in the maintenance of the balance of IL-17-producing and T-regulatory cells during pregnancy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
S. V. Shirshev, Mechanisms of Immunendocrine Control of Reproductive Processes [in Russian], Ekaterinburg (2002).
S. V. Shirshev, E. G. Orlova, S. A. Zamorina, and I. V. Nekrasova, Dokl. Akad. Nauk, 440, No 1, 132-135 (2011).
E. V. Acosta-Rodriguez, G. Napolitani, A. Lanzavecchia, and F. Sallusto, Nat. Immunol., 8, No. 9, 942-949 (2007).
F. Annunziato, L. Cosmi, F. Liotta, et al., J. Immunol., 20, No. 11, 1361-1368 (2008).
J. N. Cuellar and M. Isokawa, Neuropharmacology, 60, No. 6, 842-851 (2011).
V. D. Dixit, E. M. Schaffer, R. S. Pyle, et al., J. Clin. Invest., 114, No. 1, 57-66 (2004).
J. Fuglsang, C. Skjaerbaek, U. Espelund, et al., Clin. Endocrinol., 62, No. 5, 554-559 (2005).
L. Hardie, P. Trayhurn, D. Abramovich, and P. Fowler, Clin. Endocrinol., 47, No. 1, 101-106 (1997).
N.Hattori, T. Saito, T. Yagyu, et al., J. Clin. Endocrinol. Metab., 86, No. 9, 4284-4291 (2001).
J. Heikkinen, M. Mottonen, A. Alanen, and O. Lassila, Clin. Exp. Immunol., 136, No. 2, 373-378 (2004).
K. Ichiyama, H. Yoshida, Y. Wakabayashi, et al., J. Biol. Chem., 283, No. 25, 17,003-17,008 (2008).
Y. S. Liu, L. Wu, X. H. Tong, et al., Am. J. Reprod. Immunol., 65, No. 5, 503-511 (2011).
G. Matarese, C. Procaccini, V. De Rosa, et al., Trends Mol. Med., 16, No. 6, 247-256 (2010).
C. Procaccini, V. De Rosa, M. Galgani, et al., Immunity, 33, No. 6, 929-941 (2010).
M. Tena-Sempere, Neuroendocrinology, 86, No. 3, 229-241 (2007).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 12, pp. 786-790, December, 2013
Rights and permissions
About this article
Cite this article
Orlova, E.G., Shirshev, S.V. Role of Leptin and Ghrelin in Induction of Differentiation of IL-17-Producing and T-Regulatory Cells. Bull Exp Biol Med 156, 819–822 (2014). https://doi.org/10.1007/s10517-014-2459-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-014-2459-3