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Specific Effects of Chondroitin Sulfate-Modified Hyaluronidase on the Function of Progenitor Cells

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Bulletin of Experimental Biology and Medicine Aims and scope

We have demonstrated the possibility of stimulation of the function of various types of precursor cells with hyaluronidase modified with chondroitin sulfate. Parenteral administration of modified hyaluronidase increased the number of fibroblast, granulomonocyte, and erythroid CFU in the hemopoietic tissue. The changes in the pool of mesenchymal progenitor cells were more pronounced in comparison with those induced by native enzyme.

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Authors and Affiliations

  1. Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    G. N. Zyuz’kov, V. V. Zhdanov, E. V. Udut, A. D. Turashev, L. A. Miroshnichenko, E. V. Simanina, A. V. Chaikovskii, M. Yu. Minakova, V. V. Udut & A. M. Dygai

  2. Russian Cardiology Research and Production Center, Ministry of Health of the Russian Federation, Moscow, Russia

    A.V. Maksimenko

  3. Scientific Future Management, Novosibirsk, Russia

    A. V. Artamonov, A. A. Bekarev & P. G. Madonov

Authors
  1. G. N. Zyuz’kov
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  2. A.V. Maksimenko
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  3. V. V. Zhdanov
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  4. E. V. Udut
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  5. A. D. Turashev
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  6. L. A. Miroshnichenko
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  7. E. V. Simanina
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  8. A. V. Chaikovskii
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  9. M. Yu. Minakova
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  10. A. V. Artamonov
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  11. A. A. Bekarev
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  12. P. G. Madonov
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  13. V. V. Udut
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  14. A. M. Dygai
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Corresponding author

Correspondence to G. N. Zyuz’kov.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 145-152, October, 2013

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Zyuz’kov, G.N., Maksimenko, A., Zhdanov, V.V. et al. Specific Effects of Chondroitin Sulfate-Modified Hyaluronidase on the Function of Progenitor Cells. Bull Exp Biol Med 156, 544–547 (2014). https://doi.org/10.1007/s10517-014-2393-4

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  • DOI: https://doi.org/10.1007/s10517-014-2393-4

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