Antibodies (IgG) to gonadotropin-releasing hormone were measured by ELISA in blood serum of women with miscarriage and men with infertility. Spontaneous production of antibodies to gonadotropin-releasing hormone was observed during miscarriage and male infertility: the mean level of antibodies in these groups was higher than in healthy women and men (p<0.0001). ROC-analysis showed that test for IgG to gonadotropin-releasing hormone has high sensitivity, specificity, and AUC (more that 70%, 90%, and 0.8, respectively). Thus, the presence of antibodies to gonadotropin-releasing hormone was associated with impairments of human reproductive function.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
I. V. Menzhinskaya, O. S. Beznoschenko, P. A. Kiryuschenkov, and L. V. Van’ko, Akush. Gin., No. 1, 47–51 (2011).
I. V. Menzhinskaya, G. V. Ter-Avanesov, Yu. A. Gavrilov, et al., Akush. Gin., No. 5, 54–57 (2011).
D. Alemayehu, and K. H. Zou, Acad. Radiol., 19, No. 12, 1457–1464 (2012).
B. Ohlsson, K. Sjoberg, R. Alm, and G. N. Fredrikson, Neurogastroenterol. Motil., 23, No. 11, 1000–1006 (2011).
B. Ohlsson, B. Veress, S. Janciauskiene, et al., Gastroenterology, 132, No. 1, 45–51 (2007).
L. M. Pennell, C. L. Galligan, and E. N. Fish, J. Autoimm., 38, Nos. 2–3, J282-J291 (2012).
R. Pierantoni, G. Cobellis, R. Meccariello, et al., Ann. N.Y. Acad. Sci., 1163, 279–291 (2009).
F. Raga, E. M. Casan, and F. Bonilla-Musoles, J. Obstet. Gynaecol. Res., 34, No. 4, 464–472 (2008).
T. M. Siler-Khodr, C. B. Smikle, K. A. Sorem, et al., Early Pregnancy, 3, No. 1, 10–14 (1997).
G. P. Talwar, H. K. Vyas, S. Purswani, and J. C. Gupta, J. Reprod. Immunol., 83, Nos. 1–2, 158–163 (2009).
H. M. Wu, H. S. Wang, H. Y. Huang, et al., Reproduction, 137, No. 5, 769–777 (2009).
B. Yu. J. Ruman, and G. Christman, Fertil. Steril., 95, No. 2, 465–473 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 6, pp. 675–678, June, 2013
Rights and permissions
About this article
Cite this article
Menzhinskaya, I.V., Van’ko, L.V., Kiryushchenkov, P.A. et al. Correlation between Antibodies to Gonadotropin-Releasing Hormone and Reproductive Disorders in Humans. Bull Exp Biol Med 155, 715–717 (2013). https://doi.org/10.1007/s10517-013-2234-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-013-2234-x