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Heart Rate Regulation at Different Levels of Convulsive Readiness

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Heart rate variability parameters and the level of convulsive readiness during pentylenetetrazole-induced kindling in rats were analyzed using telemetric ECG and EEG monitoring. Analysis of ECG recorded over many days showed that heart rate variability was equally reduced after 7 and 27 days of kindling irrespective of the level of convulsive readiness. Reduced sympathovagal index after 7 days of kindling showed the compensatory character of changes. However, compensatory mechanisms cannot prevent high risk of life-threatening arrhythmias. High convulsive readiness after 27 days of kindling was accompanied by a shift of autonomic balance towards the increase in sympathetic tone, which may lead to decompensation and transition to a prenosological state.

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Authors and Affiliations

  1. Department of Anatomy and Physiology of Humans and Animals, Moscow State Pedagogical University, Moscow, Russia

    M. L. Mamalyga

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  1. M. L. Mamalyga
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Correspondence to M. L. Mamalyga.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 4, pp. 415-418, April, 2013

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Mamalyga, M.L. Heart Rate Regulation at Different Levels of Convulsive Readiness. Bull Exp Biol Med 155, 425–428 (2013). https://doi.org/10.1007/s10517-013-2168-3

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  • DOI: https://doi.org/10.1007/s10517-013-2168-3

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